3pn1: Difference between revisions

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[[Image:3pn1.png|left|200px]]


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==Novel Bacterial NAD+-dependent DNA Ligase Inhibitors with Broad Spectrum Potency and Antibacterial Efficacy In Vivo==
The line below this paragraph, containing "STRUCTURE_3pn1", creates the "Structure Box" on the page.
<StructureSection load='3pn1' size='340' side='right'caption='[[3pn1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3pn1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PN1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PN1 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IVH:2-(BUTYLSULFANYL)ADENOSINE'>IVH</scene>, <scene name='pdbligand=IWH:1-(2,4-DIMETHYLBENZYL)-6-OXO-1,6-DIHYDROPYRIDINE-3-CARBOXAMIDE'>IWH</scene></td></tr>
{{STRUCTURE_3pn1|  PDB=3pn1  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pn1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pn1 OCA], [https://pdbe.org/3pn1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pn1 RCSB], [https://www.ebi.ac.uk/pdbsum/3pn1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pn1 ProSAT]</span></td></tr>
 
</table>
===Novel Bacterial NAD+-dependent DNA Ligase Inhibitors with Broad Spectrum Potency and Antibacterial Efficacy In Vivo===
== Function ==
 
[https://www.uniprot.org/uniprot/DNLJ_HAEIN DNLJ_HAEIN] DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity).
 
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The line below this paragraph, {{ABSTRACT_PUBMED_21189350}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 21189350 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21189350}}
 
==About this Structure==
[[3pn1]] is a 1 chain structure of [[DNA ligase]] with sequence from [http://en.wikipedia.org/wiki/Haemophilus_influenzae Haemophilus influenzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PN1 OCA].  


==See Also==
==See Also==
*[[DNA ligase]]
*[[DNA ligase 3D structures|DNA ligase 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:021189350</ref><references group="xtra"/>
[[Category: Haemophilus influenzae]]
[[Category: Haemophilus influenzae]]
[[Category: Buurman, E.]]
[[Category: Large Structures]]
[[Category: Eakin, A.]]
[[Category: Buurman E]]
[[Category: Gao, N.]]
[[Category: Eakin A]]
[[Category: Huynh, H.]]
[[Category: Gao N]]
[[Category: Johnson, K.]]
[[Category: Huynh H]]
[[Category: Lahiri, S.]]
[[Category: Johnson K]]
[[Category: Mills, S.]]
[[Category: Lahiri S]]
[[Category: Newman, J.]]
[[Category: Mills S]]
[[Category: Shapiro, A.]]
[[Category: Newman J]]
[[Category: Stokes, S.]]
[[Category: Shapiro A]]
[[Category: Walkup, G.]]
[[Category: Stokes S]]
[[Category: Wei, Y.]]
[[Category: Walkup G]]
[[Category: Atp grasp fold]]
[[Category: Wei Y]]
[[Category: Bacteria]]
[[Category: Dna]]
[[Category: Ligase]]
[[Category: Ligase-ligase inhibitor complex]]
Retrieved from "https://proteopedia.org/3pn1"