2lk3: Difference between revisions

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[[Image:2lk3.jpg|left|200px]]


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==U2/U6 Helix I==
The line below this paragraph, containing "STRUCTURE_2lk3", creates the "Structure Box" on the page.
<StructureSection load='2lk3' size='340' side='right'caption='[[2lk3]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2lk3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LK3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LK3 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lk3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lk3 OCA], [https://pdbe.org/2lk3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lk3 RCSB], [https://www.ebi.ac.uk/pdbsum/2lk3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lk3 ProSAT]</span></td></tr>
{{STRUCTURE_2lk3|  PDB=2lk3  |  SCENE=  }}
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The U2/U6 snRNA complex is a conserved and essential component of the active spliceosome that interacts with the pre-mRNA substrate and essential protein splicing factors to promote splicing catalysis. Here we have elucidated the solution structure of a 111-nucleotide U2/U6 complex using an approach that integrates SAXS, NMR, and molecular modeling. The U2/U6 structure contains a three-helix junction that forms an extended "Y" shape. The U6 internal stem-loop (ISL) forms a continuous stack with U2/U6 Helices Ib, Ia, and III. The coaxial stacking of Helix Ib on the U6 ISL is a configuration that is similar to the Domain V structure in group II introns. Interestingly, essential features of the complex-including the U80 metal binding site, AGC triad, and pre-mRNA recognition sites-localize to one face of the molecule. This observation suggests that the U2/U6 structure is well-suited for orienting substrate and cofactors during splicing catalysis.


===U2/U6 Helix I===
Structure of the yeast U2/U6 snRNA complex.,Burke JE, Sashital DG, Zuo X, Wang YX, Butcher SE RNA. 2012 Feb 10. PMID:22328579<ref>PMID:22328579</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==About this Structure==
</div>
[[2lk3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LK3 OCA].
<div class="pdbe-citations 2lk3" style="background-color:#fffaf0;"></div>
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:022328579</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Burke, J E.]]
[[Category: Burke JE]]
[[Category: Butcher, S E.]]
[[Category: Butcher SE]]
[[Category: Sashital, D G.]]
[[Category: Sashital DG]]
[[Category: Wang, Y.]]
[[Category: Wang Y]]
[[Category: Zuo, X E.]]
[[Category: Zuo XE]]
[[Category: Bulge]]
[[Category: Rna]]
Retrieved from "https://proteopedia.org/2lk3"