3t1g: Difference between revisions

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[[Image:3t1g.png|left|200px]]


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==Engineering of organophosphate hydrolase by computational design and directed evolution==
The line below this paragraph, containing "STRUCTURE_3t1g", creates the "Structure Box" on the page.
<StructureSection load='3t1g' size='340' side='right'caption='[[3t1g]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3t1g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T1G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T1G FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3t1g|  PDB=3t1g  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t1g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t1g OCA], [https://pdbe.org/3t1g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t1g RCSB], [https://www.ebi.ac.uk/pdbsum/3t1g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t1g ProSAT]</span></td></tr>
 
</table>
===Engineering of organophosphate hydrolase by computational design and directed evolution===
== Function ==
 
[https://www.uniprot.org/uniprot/ADA_MOUSE ADA_MOUSE] Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity).
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_22306579}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 22306579 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22306579}}
 
==About this Structure==
[[3t1g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T1G OCA].  
 
==Reference==
<ref group="xtra">PMID:022306579</ref><references group="xtra"/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Stoddard, B L.]]
[[Category: Stoddard BL]]
[[Category: Takeuchi, R.]]
[[Category: Takeuchi R]]
[[Category: Artificial enzyme]]
[[Category: Computational design]]
[[Category: Directed evolution]]
[[Category: Hydrolase]]
[[Category: Hydrolysis]]
[[Category: Metallo-dependent hydrolase]]
[[Category: Organophosphate binding]]
[[Category: Tim beta/alpha-barrel]]

Latest revision as of 13:14, 14 March 2024

Engineering of organophosphate hydrolase by computational design and directed evolution

3t1g, resolution 2.35Å

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