3sar: Difference between revisions

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[[Image:3sar.png|left|200px]]


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==MUTM Slanted complex 1==
The line below this paragraph, containing "STRUCTURE_3sar", creates the "Structure Box" on the page.
<StructureSection load='3sar' size='340' side='right'caption='[[3sar]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3sar]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SAR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SAR FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CX2:2-DEOXY-5-O-{(R)-HYDROXY[(2-SULFANYLETHYL)AMINO]PHOSPHORYL}CYTIDINE'>CX2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3sar|  PDB=3sar  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sar FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sar OCA], [https://pdbe.org/3sar PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sar RCSB], [https://www.ebi.ac.uk/pdbsum/3sar PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sar ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/P84131_GEOSE P84131_GEOSE] Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity).[HAMAP-Rule:MF_00103][SAAS:SAAS020629_004_120556]


===MUTM Slanted complex 1===
==See Also==
 
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
 
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_22219368}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 22219368 is the PubMed ID number.
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{{ABSTRACT_PUBMED_22219368}}
 
==About this Structure==
[[3sar]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SAR OCA].
 
==Reference==
<ref group="xtra">PMID:022219368</ref><references group="xtra"/>
[[Category: DNA-formamidopyrimidine glycosylase]]
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
[[Category: Banerjee, A.]]
[[Category: Large Structures]]
[[Category: Qi, Y.]]
[[Category: Banerjee A]]
[[Category: Spong, M C.]]
[[Category: Qi Y]]
[[Category: Verdine, G L.]]
[[Category: Spong MC]]
[[Category: Damage search]]
[[Category: Verdine GL]]
[[Category: Disulfide crosslinking]]
[[Category: Dna damage]]
[[Category: Dna glycosylase]]
[[Category: Dna repair]]
[[Category: Dna-binding]]
[[Category: Glycosidase]]
[[Category: Hydrolase]]
[[Category: Hydrolase-dna complex]]
[[Category: Lyase]]
[[Category: Metal-binding]]
[[Category: Multifunctional enzyme]]
[[Category: Translocation]]
[[Category: Zinc-finger]]

Latest revision as of 12:52, 14 March 2024

MUTM Slanted complex 1

3sar, resolution 1.95Å

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