Fructokinase: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) New page: {{STRUCTURE_3lm9| PDB=3lm9 | SIZE=400| SCENE= |right|CAPTION=Fructokinase complex with fructose and ATP, 3lm9 }} <!-- Please use the "3D" button above this box to insert a Jmol app... |
Michal Harel (talk | contribs) No edit summary |
||
| (23 intermediate revisions by 3 users not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='' size='350' side='right' scene='48/484862/Cv/2' caption='Fructokinase with ADP and Fructose bound in the active site [[3lm9]]'> | |||
== Function == | |||
'''Fructokinase''' (FRK) catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in plants, bacteria and animals. In plants and bacteria FRK regulates starch synthesis. In animals it produces oxalate and its precursors<ref>PMID:3009653</ref>. | |||
*<scene name='48/484862/Cv/6'>Fructokinase with ADP and fructose bound in the active site</scene> ([[3lm9]]). Water molecules shown as red spheres. | |||
== Relevance == | |||
Inhibitors of FRK C may block sugar-associated metabolic syndromes<ref>PMID:23439477</ref>. | |||
== Disease == | |||
FRK deficiency in the liver causes the inherited metabolic disorder Fructosuria<ref>PMID:2992452</ref>. | |||
</StructureSection> | |||
==3D structures of fructokinase== | ==3D structures of fructokinase== | ||
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
[[2qhp]] – FRK – ''Bacterioides thetaiotamicron''<br /> | [[2qhp]] – FRK – ''Bacterioides thetaiotamicron''<br /> | ||
| Line 15: | Line 22: | ||
[[3lki]] – XfFRK + ATP<br /> | [[3lki]] – XfFRK + ATP<br /> | ||
[[3lm9]] - BsFRK + ATP + fructose – ''Bacillus subtilis''<br /> | [[3lm9]] - BsFRK + ATP + fructose – ''Bacillus subtilis''<br /> | ||
[[3ohr]] - BsFRK + ADP | [[3ohr]] - BsFRK + ADP<br /> | ||
[[2v78]], [[2var]] – FRK – ''Sulfolobus solfataricus''<br /> | |||
[[3c8u]] – FRK – ''Silicibacter''<br /> | |||
[[5ey7]] – VcFRK – ''Vibrio cholerae''<br /> | |||
[[5f11]] – VcFRK + fructose <br /> | |||
[[5f0z]], [[5ygg]] – VcFRK + fructose + ADP<br /> | |||
[[5eyn]] – VcFRK + fructose + ADP + BeF3<br /> | |||
[[7cf8]], [[7cfa]] – FRK – ''Mycobacterium marinum''<br /> | |||
[[4u7x]] – BaFRK – ''Brucella abortus''<br /> | |||
[[4wjm]] – BaFRK + AMPPNP<br /> | |||
For Hepatic fructokinase see [[Ketohexokinase]] | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | |||
Latest revision as of 06:54, 7 July 2025
| ||||||||||||
3D structures of fructokinase
Updated on 07-July-2025
3lm9 – FRK – Bacterioides thetaiotamicron
3ljs – XfFRK – Xylella fastidiosa
3hj6 – FRK – Halothermothrix orenii
3lki – XfFRK + ATP
3lm9 - BsFRK + ATP + fructose – Bacillus subtilis
3ohr - BsFRK + ADP
2v78, 2var – FRK – Sulfolobus solfataricus
3c8u – FRK – Silicibacter
5ey7 – VcFRK – Vibrio cholerae
5f11 – VcFRK + fructose
5f0z, 5ygg – VcFRK + fructose + ADP
5eyn – VcFRK + fructose + ADP + BeF3
7cf8, 7cfa – FRK – Mycobacterium marinum
4u7x – BaFRK – Brucella abortus
4wjm – BaFRK + AMPPNP
For Hepatic fructokinase see Ketohexokinase
