4dx7: Difference between revisions
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New page: '''Unreleased structure''' The entry 4dx7 is ON HOLD Authors: Eicher, T., Cha, H., Seeger, M.A., Brandstaetter, L., El-Delik, J., Bohnert, J.A., Kern, W.V., Verrey, F., Gruetter, M.G., ... |
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==Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop== | |||
<StructureSection load='4dx7' size='340' side='right'caption='[[4dx7]], [[Resolution|resolution]] 2.25Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4dx7]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DX7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4DX7 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.253Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D10:DECANE'>D10</scene>, <scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=DM2:DOXORUBICIN'>DM2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HEX:HEXANE'>HEX</scene>, <scene name='pdbligand=LMT:DODECYL-BETA-D-MALTOSIDE'>LMT</scene>, <scene name='pdbligand=LMU:DODECYL-ALPHA-D-MALTOSIDE'>LMU</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4dx7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4dx7 OCA], [https://pdbe.org/4dx7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4dx7 RCSB], [https://www.ebi.ac.uk/pdbsum/4dx7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4dx7 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ACRB_ECOLI ACRB_ECOLI] AcrAB is a drug efflux protein with a broad substrate specificity.<ref>PMID:16915237</ref> <ref>PMID:16946072</ref> <ref>PMID:17194213</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Bohnert JA]] | |||
[[Category: Brandstaetter L]] | |||
[[Category: Cha H]] | |||
[[Category: Diederichs K]] | |||
[[Category: Eicher T]] | |||
[[Category: El-Delik J]] | |||
[[Category: Gruetter MG]] | |||
[[Category: Kern WV]] | |||
[[Category: Pos KM]] | |||
[[Category: Seeger MA]] | |||
[[Category: Verrey F]] | |||
Latest revision as of 10:59, 1 March 2024
Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop
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