Sandbox 37: Difference between revisions

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{{Template:Oberholser_Sandbox_Reservation}}
{{Template:Oberholser_Sandbox_Reservation}}
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<Structure load='1AKE' size='500' frame='true' align='right' caption='Adenylate Kinase' scene='Matt's Beautiful Protein' />


='''Interferon-β'''=
The <scene name='Sandbox_37/Matt_adenylate_kinase_37/1'>Adenylate Kinase</scene> protein is shown here with alpha helices (cyan) and beta sheets (green) surrounding the non-hydrolysable substrate analogue (orange).


===Introduction===
The <scene name='Sandbox_37/Matt_helix_beta_colored/1'>Secondary Structure</scene> of the protein is shown here with alpha helices (green) and beta sheets (blue) highlighted appropriately.


===History===
The <scene name='Sandbox_37/Matt_hydrogen_bonds_good/1'>Hydrogen Bonds</scene> of chain A of the protein are highlighted in orange here.
==Structure==
<StructureSection load='1IFA' size='400' align='right' caption='Interferon-β' scene='Sandbox_37/Interferon_beta/1'></StructureSection>


Interferon-β is a relatively simple biological response modifier consisting of five <scene name='Sandbox_37/Ifnb_alpha_helices/1'>alpha helices</scene>. There are no beta sheets, but, in addition to the alpha helices, only multiple interconnecting <scene name='Sandbox_37/Ifnb_loops/1'>loop regions</scene>. Helices A, B and D run <scene name='Sandbox_37/Ifnb_parallel_abd/1'>parallel to one another</scene>, and helices C and E run <scene name='Sandbox_37/Interferon_beta/3'>anti-parallel</scene> to the other three helices.
The <scene name='Sandbox_37/Matt_hydrophobic_good/1'>Hydrophobic Interactions</scene> are shown here in red.
<ref name="Structure">PMID:20616576</ref>


<ref name="UniProt">http://www.uniprot.org/uniprot/P00784</ref>
The <scene name='Sandbox_37/Matt_hydrophilic_good/1'>Hydrophilic Interactions</scene> are shown here in black.
===Solvent Interactions===


The <scene name='Sandbox_37/Matt_solvent/1'>Solvent</scene> , which is water, is shown here in red. Water's primary location is on the outer parts of the protein, or the hydrophilic regions.


===Mechanism===
The side chains that interact with the <scene name='Sandbox_37/Matt_ligand/1'>ligand</scene> are shown here in crimson. The interactions occur with the hydrophobic side chains. The rest of the protein is faded blue.


 
The <scene name='Sandbox_37/Matt_catalytic_residues/1'>catalytic residues</scene> of this protein are shown here in lime green.
==Inhibition==
<Structure load='1IFA' size='400' frame='true' align='right' caption='Papain with leupeptin inhibitor (1IFA)' scene='Sandbox_37/Interferon_beta/2'/>
===Inhibitors of Interferon-β===
===Interferon-β as an Inhibitor===
 
==Function==
===Biochemical===
===Immunological===
 
==References==
<references />
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