3qi2: Difference between revisions

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[[Image:3qi2.png|left|200px]]


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==A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco==
The line below this paragraph, containing "STRUCTURE_3qi2", creates the "Structure Box" on the page.
<StructureSection load='3qi2' size='340' side='right'caption='[[3qi2]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3qi2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QI2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QI2 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.797&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3qi2|  PDB=3qi2  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qi2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qi2 OCA], [https://pdbe.org/3qi2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qi2 RCSB], [https://www.ebi.ac.uk/pdbsum/3qi2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qi2 ProSAT]</span></td></tr>
 
</table>
===A Galpha P-loop mutation prevents transition to the activated state: G42R bound to RGS14 GoLoco===
== Function ==
 
[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
 
== References ==
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{{ABSTRACT_PUBMED_22383884}}
 
==About this Structure==
[[3qi2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QI2 OCA].  
 
==Reference==
<ref group="xtra">PMID:022383884</ref><ref group="xtra">PMID:017603074</ref><ref group="xtra">PMID:011976690</ref><references group="xtra"/>
[[Category: Heterotrimeric G-protein GTPase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Bosch, D E.]]
[[Category: Large Structures]]
[[Category: Kimple, A J.]]
[[Category: Bosch DE]]
[[Category: Miley, M J.]]
[[Category: Kimple AJ]]
[[Category: Siderovski, D P.]]
[[Category: Miley MJ]]
[[Category: Willard, F S.]]
[[Category: Siderovski DP]]
[[Category: Adp-ribosylation]]
[[Category: Willard FS]]
[[Category: All-helical domain]]
[[Category: Arginine finger]]
[[Category: Goloco motif]]
[[Category: Gtp binding]]
[[Category: Guanine nucleotide dissociation inhibitor]]
[[Category: Lipoprotein]]
[[Category: Nucleotide binding]]
[[Category: Ras-like domain]]
[[Category: Rgs14 goloco]]
[[Category: Signaling protein]]
[[Category: Transducer]]
Retrieved from "https://proteopedia.org/3qi2"