2l0t: Difference between revisions

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[[Image:2l0t.png|left|200px]]


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==Solution structure of the complex of ubiquitin and the VHS domain of Stam2==
The line below this paragraph, containing "STRUCTURE_2l0t", creates the "Structure Box" on the page.
<StructureSection load='2l0t' size='340' side='right'caption='[[2l0t]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2l0t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L0T FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0t OCA], [https://pdbe.org/2l0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l0t RCSB], [https://www.ebi.ac.uk/pdbsum/2l0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l0t ProSAT]</span></td></tr>
{{STRUCTURE_2l0t|  PDB=2l0t  |  SCENE=  }}
</table>
 
== Function ==
===Solution structure of the complex of ubiquitin and the VHS domain of Stam2===
[https://www.uniprot.org/uniprot/STAM2_HUMAN STAM2_HUMAN] Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
 
 
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The line below this paragraph, {{ABSTRACT_PUBMED_21121635}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 21121635 is the PubMed ID number.
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{{ABSTRACT_PUBMED_21121635}}
 
==About this Structure==
[[2l0t]] is a 2 chain structure of [[Ubiquitin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0T OCA].  


==See Also==
==See Also==
*[[Ubiquitin]]
*[[3D structures of ubiquitin|3D structures of ubiquitin]]
 
__TOC__
==Reference==
</StructureSection>
<ref group="xtra">PMID:021121635</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hoeller, D.]]
[[Category: Large Structures]]
[[Category: Lancelin, J.]]
[[Category: Hoeller D]]
[[Category: Lange, A.]]
[[Category: Lancelin J]]
[[Category: Marcillat, O.]]
[[Category: Lange A]]
[[Category: Walker, O.]]
[[Category: Marcillat O]]
[[Category: Wienk, H.]]
[[Category: Walker O]]
[[Category: Endosome]]
[[Category: Wienk H]]
[[Category: Protein transport]]
[[Category: Stam2]]
[[Category: Transport]]
[[Category: Ubiquitin]]
[[Category: Vh]]
Retrieved from "https://proteopedia.org/2l0t"