4e1p: Difference between revisions

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'''Unreleased structure'''


The entry 4e1p is ON HOLD
==Crystal structure of the dimerization domain of Lsr2 from Mycobacterium tuberculosis in the P 1 21 1 space group==
 
<StructureSection load='4e1p' size='340' side='right'caption='[[4e1p]], [[Resolution|resolution]] 1.73&Aring;' scene=''>
Authors: Summers, E.L., Meindl, K., Uson, I., Arcus, V.L.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4e1p]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E1P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E1P FirstGlance]. <br>
Description: Crystal structure of dimerisation domain of Lsr2 from Mycobacterium tuberculosis
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.728&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e1p OCA], [https://pdbe.org/4e1p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e1p RCSB], [https://www.ebi.ac.uk/pdbsum/4e1p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e1p ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LSR2_MYCTU LSR2_MYCTU] DNA-bridging protein that has both architectural and regulatory roles. Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments. Represses expression of multiple genes involved in a broad range of cellular processes, including major virulence factors or antibiotic-induced genes, such as iniBAC or efpA. May coordinate global gene regulation and virulence. Also protects mycobacteria against reactive oxygen intermediates during macrophage infection by acting as a physical barrier to DNA degradation.<ref>PMID:17590082</ref> <ref>PMID:18187505</ref> <ref>PMID:19237572</ref> <ref>PMID:20133735</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Arcus VL]]
[[Category: Meindl K]]
[[Category: Summers EL]]
[[Category: Uson I]]
Retrieved from "https://proteopedia.org/4e1p"