4e20: Difference between revisions
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New page: '''Unreleased structure''' The entry 4e20 is ON HOLD Authors: Argiriadi, M.A., Talanian, R.V., Borhani, D.W. Description: Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibi... |
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==Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor== | |||
<StructureSection load='4e20' size='340' side='right'caption='[[4e20]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4e20]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E20 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E20 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0MY:N-[4-(3-AMINO-1H-INDAZOL-5-YL)PHENYL]-3-CHLOROBENZENESULFONAMIDE'>0MY</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e20 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e20 OCA], [https://pdbe.org/4e20 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e20 RCSB], [https://www.ebi.ac.uk/pdbsum/4e20 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e20 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TYK2_MOUSE TYK2_MOUSE] Involved in intracellular signal transduction by amplifying type I and type II IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain. Plays an essential role in promoting selective immune responses, including innate host defense mechanisms and specific antiviral activities. | |||
==See Also== | |||
*[[Tyrosine kinase 3D structures|Tyrosine kinase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Argiriadi MA]] | |||
[[Category: Borhani DW]] | |||
[[Category: Talanian RV]] | |||
Latest revision as of 11:01, 1 March 2024
Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor
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