Polyamine oxidase: Difference between revisions

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{{STRUCTURE_3l1r|  PDB=3l1r  | SIZE=400| SCENE= |right|CAPTION=Yeast polyamine oxidase Fms1 complex  with spermidine, [[3l1r]] }}
<StructureSection load='' size='350' side='right' scene='48/486448/Cv/1' caption='lycosylated FAD containing polyamine oxidase dimer complex  with spermidine, sulfate and Cl- ion (green), [[3l1r]]' >  
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'''Polyamine oxidase''' (PAO) catalyzes the conversion of N-acetylspermine, molecular oxygen  and water to N-acetylspermidine, 3-aminopropanol and hydrogen peroxide.  PAO via its production of hydrogen peroxide, is one of the key elements for oxidative burst which induces programmed cell death.  PAO is involved in polyamine catabolism and uses FAD as a cofactor.




[[1yy5]], [[1rsg]], [[1xpq]] – yPAO – yeast<br />
'''Polyamine oxidase''' (PAO) catalyzes the conversion of N-acetylspermine, molecular oxygen  and water to N-acetylspermidine, 3-aminopropanol and hydrogen peroxide.  PAO via its production of hydrogen peroxide, is one of the key elements for oxidative burst which induces programmed cell death.  PAO is involved in polyamine catabolism and uses FAD as a cofactor<ref>PMID:8584670</ref>.<br />
[[3kpf]] – yPAO (mutant)<br />
'''Spermine oxidase''' (PAO-1) oxydizes spermine<ref>PMID:21809080</ref>.<br />
[[1b37]], [[1b5q]], [[1h81]] – mPAO FAD-binding domain – maize
*<scene name='48/486448/Cv/7'>FAD binding site</scene>. Water molecules are shown as red spheres.
*<scene name='48/486448/Cv/5'>Spermidine binding site</scene>.
*<scene name='48/486448/Cv/6'>Whole active site</scene>.
</StructureSection>
==3D structures of polyamine oxidase==


'''Polyamine oxidase binary complex'''
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|


[[1h82]], [[1h83]], [[1h84]], [[1h86]] – mPAO FAD-binding domain + polyamine<br />
*Polyamine oxidase
[[1z6l]] - yPAO + polyamine<br />
 
[[3bi2]], [[3bi4]], [[3bi5]] – yPAO + inhibitor<br />
**[[1yy5]], [[1rsg]], [[1xpq]] – yPAO – yeast<br />
[[3bnm]], [[3bnu]], [[3cnd]] – yPAO + spermine derivative<br />
**[[3kpf]], [[4ech]], [[4gdp]] – yPAO (mutant)<br />
[[3cn8]], [[3cnp]], [[3cns]], [[3cnt]] - yPAO + spermidine derivative<br />
**[[1b37]], [[1b5q]], [[1h81]] – mPAO FAD-binding domain – maize
[[3l1r]] - yPAO (mutant) + spermidine
 
*Polyamine oxidase binary complex
 
**[[1h82]], [[1h83]], [[1h84]], [[1h86]] – mPAO FAD-binding domain + polyamine<br />
**[[1z6l]] - yPAO + polyamine<br />
**[[3bi2]], [[3bi4]], [[3bi5]] – yPAO + inhibitor<br />
**[[3bnm]], [[3bnu]], [[3cnd]] – yPAO + spermine derivative<br />
**[[3cn8]], [[3cnp]], [[3cns]], [[3cnt]] - yPAO + spermidine derivative<br />
**[[3l1r]] - mPAO (mutant) FAD-binding domain + spermidine<br />
**[[3ku9]] - mPAO FAD-binding domain (mutant) + spermine<br />
 
*Spermine oxidase or PAO-1
 
**[[7oxl]] – hPAO-1 + FAD derivative – human<br />
**[[7oy0]] – hPAO-1 + FAD derivative + inhibitor<br />
 
}}
== References ==
<references/>
[[Category:Topic Page]]
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