3f7t: Difference between revisions
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< | ==Structure of active IspH shows a novel fold with a [3Fe-4S] cluster in the catalytic centre== | ||
<StructureSection load='3f7t' size='340' side='right'caption='[[3f7t]], [[Resolution|resolution]] 1.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3f7t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3F7T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3F7T FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=POP:PYROPHOSPHATE+2-'>POP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3f7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3f7t OCA], [https://pdbe.org/3f7t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3f7t RCSB], [https://www.ebi.ac.uk/pdbsum/3f7t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3f7t ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ISPH_ECOLI ISPH_ECOLI] Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Is also involved in penicillin tolerance and control of the stringent response. Seems to directly or indirectly interact with RelA to maintain it in an inactive form during normal growth.<ref>PMID:19569147</ref> <ref>PMID:20080550</ref> <ref>PMID:22137895</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f7/3f7t_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3f7t ConSurf]. | |||
<div style="clear:both"></div> | |||
== | ==See Also== | ||
*[[4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures|4-hydroxy-3-methylbut-2-enyl diphosphate reductase 3D structures]] | |||
== References == | |||
<references/> | |||
[[ | __TOC__ | ||
</StructureSection> | |||
== | [[Category: Escherichia coli K-12]] | ||
< | [[Category: Large Structures]] | ||
[[Category: | [[Category: Bacher A]] | ||
[[Category: | [[Category: Eisenreich W]] | ||
[[Category: Bacher | [[Category: Eppinger J]] | ||
[[Category: Eisenreich | [[Category: Graewert T]] | ||
[[Category: Eppinger | [[Category: Groll M]] | ||
[[Category: Graewert | [[Category: Rohdich F]] | ||
[[Category: Groll | |||
[[Category: Rohdich | |||
Latest revision as of 09:16, 13 August 2026
Structure of active IspH shows a novel fold with a [3Fe-4S] cluster in the catalytic centre
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