3qd2: Difference between revisions

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[[Image:3qd2.png|left|200px]]


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==Crystal structure of mouse PERK kinase domain==
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<StructureSection load='3qd2' size='340' side='right'caption='[[3qd2]], [[Resolution|resolution]] 2.81&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3qd2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QD2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QD2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
{{STRUCTURE_3qd2|  PDB=3qd2  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qd2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qd2 OCA], [https://pdbe.org/3qd2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qd2 RCSB], [https://www.ebi.ac.uk/pdbsum/3qd2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qd2 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The endoplasmic reticulum (ER) unfolded protein response (UPR) is comprised of several intracellular signaling pathways that alleviate ER stress. The ER-localized transmembrane kinase PERK is one of three major ER stress transducers. Oligomerization of PERK's N-terminal ER luminal domain by ER stress promotes PERK trans-autophosphorylation of the C-terminal cytoplasmic kinase domain at multiple residues including Thr980 on the kinase activation loop. Activated PERK phosphorylates Ser51 of the alpha-subunit of translation initiation factor 2 (eIF2alpha), which inhibits initiation of protein synthesis and reduces the load of unfolded proteins entering the ER. The crystal structure of PERK's kinase domain has been determined to 2.8 A resolution. The structure resembles the back-to-back dimer observed in the related eIF2alpha kinase PKR. Phosphorylation of Thr980 stabilizes both the activation loop and helix alphaG in the C-terminal lobe, preparing the latter for eIF2alpha binding. The structure suggests conservation in the mode of activation of eIF2alpha kinases and is consistent with a `line-up' model for PERK activation triggered by oligomerization of its luminal domain.


===Crsytal structure of mouse PERK kinase domain===
The structure of the PERK kinase domain suggests the mechanism for its activation.,Cui W, Li J, Ron D, Sha B Acta Crystallogr D Biol Crystallogr. 2011 May;67(Pt 5):423-8. Epub 2011 Apr 13. PMID:21543844<ref>PMID:21543844</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
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<references/>
{{ABSTRACT_PUBMED_21543844}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[3qd2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QD2 OCA].
 
==Reference==
<ref group="xtra">PMID:021543844</ref><references group="xtra"/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Bingdong S]]
[[Category: Bingdong, S.]]
[[Category: David R]]
[[Category: David, R.]]
[[Category: Jingzhi L]]
[[Category: Jingzhi, L.]]
[[Category: Wenjun C]]
[[Category: Wenjun, C.]]
[[Category: Eif2a kinase]]
[[Category: Gene regulation]]
[[Category: Phosphoryalation]]
Retrieved from "https://proteopedia.org/3qd2"