4ae4: Difference between revisions

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[[Image:4ae4.jpg|left|200px]]


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==The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a novel SOUBA domain==
The line below this paragraph, containing "STRUCTURE_4ae4", creates the "Structure Box" on the page.
<StructureSection load='4ae4' size='340' side='right'caption='[[4ae4]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[4ae4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AE4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AE4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=MSO:SELENOMETHIONINE+SELENOXIDE'>MSO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene></td></tr>
{{STRUCTURE_4ae4|  PDB=4ae4  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ae4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ae4 OCA], [https://pdbe.org/4ae4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ae4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ae4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ae4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UBAP1_HUMAN UBAP1_HUMAN]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The endosomal sorting complexes required for transport (ESCRTs) facilitate endosomal sorting of ubiquitinated cargo, MVB biogenesis, late stages of cytokinesis, and retroviral budding. Here we show that ubiquitin associated protein 1 (UBAP1), a subunit of human ESCRT-I, coassembles in a stable 1:1:1:1 complex with Vps23/TSG101, VPS28, and VPS37. The X-ray crystal structure of the C-terminal region of UBAP1 reveals a domain that we describe as a solenoid of overlapping UBAs (SOUBA). NMR analysis shows that each of the three rigidly arranged overlapping UBAs making up the SOUBA interact with ubiquitin. We demonstrate that UBAP1-containing ESCRT-I is essential for degradation of antiviral cell-surface proteins, such as tetherin (BST-2/CD317), by viral countermeasures, namely, the HIV-1 accessory protein Vpu and the Kaposi sarcoma-associated herpesvirus (KSHV) ubiquitin ligase K5.


===The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a novel SOUBA domain===
The UBAP1 Subunit of ESCRT-I Interacts with Ubiquitin via a SOUBA Domain.,Agromayor M, Soler N, Caballe A, Kueck T, Freund SM, Allen MD, Bycroft M, Perisic O, Ye Y, McDonald B, Scheel H, Hofmann K, Neil SJ, Martin-Serrano J, Williams RL Structure. 2012 Mar 7;20(3):414-28. PMID:22405001<ref>PMID:22405001</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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(as it appears on PubMed at http://www.pubmed.gov), where 22405001 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_22405001}}
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</StructureSection>
==About this Structure==
[[4ae4]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AE4 OCA].
 
==Reference==
<ref group="xtra">PMID:022405001</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Agromayor, M.]]
[[Category: Large Structures]]
[[Category: Allen, M D.]]
[[Category: Agromayor M]]
[[Category: Bycroft, M.]]
[[Category: Allen MD]]
[[Category: Caballe, A.]]
[[Category: Bycroft M]]
[[Category: Freund, S M.]]
[[Category: Caballe A]]
[[Category: Hofmann, K.]]
[[Category: Freund SM]]
[[Category: Kueck, T.]]
[[Category: Hofmann K]]
[[Category: Martin-Serrano, J.]]
[[Category: Kueck T]]
[[Category: Mcdonald, B.]]
[[Category: Martin-Serrano J]]
[[Category: Neil, S J.D.]]
[[Category: McDonald B]]
[[Category: Perisic, O.]]
[[Category: Neil SJD]]
[[Category: Scheel, H.]]
[[Category: Perisic O]]
[[Category: Soler, N.]]
[[Category: Scheel H]]
[[Category: Williams, R L.]]
[[Category: Soler N]]
[[Category: Ye, Y.]]
[[Category: Williams RL]]
[[Category: Endosomal sorting]]
[[Category: Ye Y]]
[[Category: Hiv-1]]
[[Category: Monoubiquitin]]
[[Category: Protein transport]]
[[Category: Tetherin]]
[[Category: Vpu]]
Retrieved from "https://proteopedia.org/4ae4"