3u82: Difference between revisions

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[[Image:3u82.jpg|left|200px]]


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==Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion==
The line below this paragraph, containing "STRUCTURE_3u82", creates the "Structure Box" on the page.
<StructureSection load='3u82' size='340' side='right'caption='[[3u82]], [[Resolution|resolution]] 3.16&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3u82]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_alphaherpesvirus_1_strain_17 Human alphaherpesvirus 1 strain 17]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U82 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U82 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.164&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u82 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u82 OCA], [https://pdbe.org/3u82 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u82 RCSB], [https://www.ebi.ac.uk/pdbsum/3u82 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u82 ProSAT]</span></td></tr>
{{STRUCTURE_3u82|  PDB=3u82  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/GD_HHV11 GD_HHV11] Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM, PVRL1 and 3-O-sulfated heparan sulfate (By similarity). May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Multiple surface envelope proteins are involved in the human herpes simplex virus type 1 entry and fusion. Among them, glycoprotein D (gD) has an important role by binding to the host receptors such as herpes virus entry mediator and nectin-1. Although the complex structure of gD with herpes virus entry mediator has been established, the binding mode of gD with the nectin-1 is elusive. Nectin-1 is a member of the immunoglobulin (Ig)-like (three Ig-like domains) cell adhesion molecules and is believed to form a homodimer to exert its functions. Here we report the complex structure of gD and nectin-1 (three Ig domains), revealing that gD binds the first Ig domain of nectin-1 in a similar mode to the nectin-1 homodimer interaction. The key amino acids responsible for nectin-1 dimerization are also used for gD/nectin-1 binding. This result indicates that binding of gD to nectin-1 would preclude the nectin-1 dimerization, consequently abolishing its cell adhesion function.


===Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion===
Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion.,Zhang N, Yan J, Lu G, Guo Z, Fan Z, Wang J, Shi Y, Qi J, Gao GF Nat Commun. 2011 Dec 6;2:577. doi: 10.1038/ncomms1571. PMID:22146396<ref>PMID:22146396</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3u82" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_22146396}}, adds the Publication Abstract to the page
*[[Glycoproteins B and D|Glycoproteins B and D]]
(as it appears on PubMed at http://www.pubmed.gov), where 22146396 is the PubMed ID number.
*[[Poliovirus receptor-related protein|Poliovirus receptor-related protein]]
-->
== References ==
{{ABSTRACT_PUBMED_22146396}}
<references/>
 
__TOC__
==About this Structure==
</StructureSection>
[[3u82]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_herpesvirus_1 Human herpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U82 OCA].
 
==Reference==
<ref group="xtra">PMID:022146396</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Human herpesvirus 1]]
[[Category: Human alphaherpesvirus 1 strain 17]]
[[Category: Fan, Z.]]
[[Category: Large Structures]]
[[Category: Gao, G F.]]
[[Category: Fan Z]]
[[Category: Guo, Z.]]
[[Category: Gao GF]]
[[Category: Lu, G.]]
[[Category: Guo Z]]
[[Category: Qi, J.]]
[[Category: Lu G]]
[[Category: Shi, Y.]]
[[Category: Qi J]]
[[Category: Wang, J.]]
[[Category: Shi Y]]
[[Category: Yan, J.]]
[[Category: Wang J]]
[[Category: Zhang, N.]]
[[Category: Yan J]]
[[Category: Binding mode]]
[[Category: Zhang N]]
[[Category: Hsv-1 gd]]
[[Category: Nectin-1]]
[[Category: Nectin-1 dimerization preclusion]]
[[Category: Viral protein-cell adhesion complex]]

Latest revision as of 17:35, 1 November 2023

Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion

3u82, resolution 3.16Å

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