3u83: Difference between revisions

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[[Image:3u83.jpg|left|200px]]


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==Crystal structure of nectin-1==
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<StructureSection load='3u83' size='340' side='right'caption='[[3u83]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3u83]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U83 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U83 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.499&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG6:1-(2-METHOXY-ETHOXY)-2-{2-[2-(2-METHOXY-ETHOXY]-ETHOXY}-ETHANE'>PG6</scene></td></tr>
{{STRUCTURE_3u83|  PDB=3u83  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u83 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u83 OCA], [https://pdbe.org/3u83 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u83 RCSB], [https://www.ebi.ac.uk/pdbsum/3u83 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u83 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/NECT1_HUMAN NECT1_HUMAN] Cleft lip/palate;Isolated cleft lip;Cleft lip and alveolus;Cleft lip/palate-ectodermal dysplasia syndrome. The disease is caused by variants affecting the gene represented in this entry.  The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/NECT1_HUMAN NECT1_HUMAN] Promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4. Has some neurite outgrowth-promoting activity.<ref>PMID:21980294</ref>  (Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV.<ref>PMID:7721102</ref> <ref>PMID:9657005</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Multiple surface envelope proteins are involved in the human herpes simplex virus type 1 entry and fusion. Among them, glycoprotein D (gD) has an important role by binding to the host receptors such as herpes virus entry mediator and nectin-1. Although the complex structure of gD with herpes virus entry mediator has been established, the binding mode of gD with the nectin-1 is elusive. Nectin-1 is a member of the immunoglobulin (Ig)-like (three Ig-like domains) cell adhesion molecules and is believed to form a homodimer to exert its functions. Here we report the complex structure of gD and nectin-1 (three Ig domains), revealing that gD binds the first Ig domain of nectin-1 in a similar mode to the nectin-1 homodimer interaction. The key amino acids responsible for nectin-1 dimerization are also used for gD/nectin-1 binding. This result indicates that binding of gD to nectin-1 would preclude the nectin-1 dimerization, consequently abolishing its cell adhesion function.


===Crystal structure of nectin-1===
Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion.,Zhang N, Yan J, Lu G, Guo Z, Fan Z, Wang J, Shi Y, Qi J, Gao GF Nat Commun. 2011 Dec 6;2:577. doi: 10.1038/ncomms1571. PMID:22146396<ref>PMID:22146396</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3u83" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_22146396}}, adds the Publication Abstract to the page
*[[Poliovirus receptor-related protein|Poliovirus receptor-related protein]]
(as it appears on PubMed at http://www.pubmed.gov), where 22146396 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_22146396}}
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</StructureSection>
==About this Structure==
[[3u83]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U83 OCA].
 
==Reference==
<ref group="xtra">PMID:022146396</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Fan, Z.]]
[[Category: Large Structures]]
[[Category: Gao, G F.]]
[[Category: Fan Z]]
[[Category: Guo, Z.]]
[[Category: Gao GF]]
[[Category: Lu, G.]]
[[Category: Guo Z]]
[[Category: Qi, J.]]
[[Category: Lu G]]
[[Category: Shi, Y.]]
[[Category: Qi J]]
[[Category: Wang, J.]]
[[Category: Shi Y]]
[[Category: Yan, J.]]
[[Category: Wang J]]
[[Category: Zhang, N.]]
[[Category: Yan J]]
[[Category: Cell adhesion]]
[[Category: Zhang N]]
[[Category: Hinge region plasiticity]]
[[Category: Nectin-1]]
Retrieved from "https://proteopedia.org/3u83"