2lnz: Difference between revisions

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[[Image:2lnz.png|left|200px]]


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==Solution structure of the Get5 carboxyl domain from S. cerevisiae==
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<StructureSection load='2lnz' size='340' side='right'caption='[[2lnz]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2lnz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LNZ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lnz OCA], [https://pdbe.org/2lnz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lnz RCSB], [https://www.ebi.ac.uk/pdbsum/2lnz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lnz ProSAT]</span></td></tr>
{{STRUCTURE_2lnz|  PDB=2lnz  |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/MDY2_YEAST MDY2_YEAST] Required for efficient mating. Involved in the production of alpha-factor, the KAR9 and TUB1 location to the shmoo tip and nuclear migration into pheromone-induced shmoos.<ref>PMID:10514570</ref> <ref>PMID:16390866</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Tail-anchored trans-membrane proteins are targeted to membranes post-translationally. The proteins Get4 and Get5 form an obligate complex that catalyzes the transfer of tail-anchored proteins destined to the endoplasmic reticulum from Sgt2 to the cytosolic targeting factor Get3. Get5 forms a homodimer mediated by its carboxyl domain. We show here that a conserved motif exists within the carboxyl domain. A high resolution crystal structure and solution NMR structures of this motif reveal a novel and stable helical dimerization domain. We additionally determined a solution NMR structure of a divergent fungal homolog, and comparison of these structures allows annotation of specific stabilizing interactions. Using solution x-ray scattering and the structures of all folded domains, we present a model of the full-length Get4/Get5 complex.


===Solution structure of the Get5 carboxyl domain from S. cerevisiae===
Get5 Carboxyl-terminal Domain Is a Novel Dimerization Motif That Tethers an Extended Get4/Get5 Complex.,Chartron JW, Vandervelde DG, Rao M, Clemons WM Jr J Biol Chem. 2012 Mar 9;287(11):8310-7. Epub 2012 Jan 17. PMID:22262836<ref>PMID:22262836</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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(as it appears on PubMed at http://www.pubmed.gov), where 22262836 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_22262836}}
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</StructureSection>
==About this Structure==
[[Category: Large Structures]]
[[2lnz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LNZ OCA].
[[Category: Saccharomyces cerevisiae S288C]]
 
[[Category: Chartron JW]]
==Reference==
[[Category: Clemons Jr WM]]
<ref group="xtra">PMID:022262836</ref><references group="xtra"/>
[[Category: Rao M]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Vandervelde DG]]
[[Category: Chartron, J W.]]
[[Category: Clemons, W M.]]
[[Category: Rao, M.]]
[[Category: Vandervelde, D G.]]
[[Category: Dimerization]]
[[Category: Homodimerization]]
[[Category: Protein binding]]
Retrieved from "https://proteopedia.org/2lnz"