3r58: Difference between revisions

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[[Image:3r58.jpg|left|200px]]


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==AKR1C3 complex with naproxen==
The line below this paragraph, containing "STRUCTURE_3r58", creates the "Structure Box" on the page.
<StructureSection load='3r58' size='340' side='right'caption='[[3r58]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3r58]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R58 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3R58 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=NPS:(2S)-2-(6-METHOXYNAPHTHALEN-2-YL)PROPANOIC+ACID'>NPS</scene></td></tr>
{{STRUCTURE_3r58|  PDB=3r58  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3r58 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3r58 OCA], [https://pdbe.org/3r58 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3r58 RCSB], [https://www.ebi.ac.uk/pdbsum/3r58 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3r58 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AK1C3_HUMAN AK1C3_HUMAN] Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.


===AKR1C3 complex with naproxen===
==See Also==
 
*[[Prostaglandin F synthase 3D structures|Prostaglandin F synthase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
[[3r58]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R58 OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Flanagan, J U.]]
[[Category: Large Structures]]
[[Category: Squire, C J.]]
[[Category: Flanagan JU]]
[[Category: Teague, R M.]]
[[Category: Squire CJ]]
[[Category: Yosaatmadja, Y.]]
[[Category: Teague RM]]
[[Category: Aldo-keto reductase]]
[[Category: Yosaatmadja Y]]
[[Category: Nitro reductase]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Tim barrel]]
Retrieved from "https://proteopedia.org/3r58"