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[[Image:3nad.png|left|200px]]


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==Crystal Structure of Phenolic Acid Decarboxylase from Bacillus pumilus UI-670==
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<StructureSection load='3nad' size='340' side='right'caption='[[3nad]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3nad]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_pumilus Bacillus pumilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NAD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NAD FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3nad|  PDB=3nad  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nad FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nad OCA], [https://pdbe.org/3nad PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nad RCSB], [https://www.ebi.ac.uk/pdbsum/3nad PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nad ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q45361_BACPU Q45361_BACPU]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The decarboxylation of phenolic acids, including ferulic and p-coumaric acids, to their corresponding vinyl derivatives is of importance in the flavouring and polymer industries. Here, the crystal structure of phenolic acid decarboxylase (PAD) from Bacillus pumilus strain UI-670 is reported. The enzyme is a 161-residue polypeptide that forms dimers both in the crystal and in solution. The structure of PAD as determined by X-ray crystallography revealed a beta-barrel structure and two alpha-helices, with a cleft formed at one edge of the barrel. The PAD structure resembles those of the lipocalin-fold proteins, which often bind hydrophobic ligands. Superposition of structurally related proteins bound to their cognate ligands shows that they and PAD bind their ligands in a conserved location within the beta-barrel. Analysis of the residue-conservation pattern for PAD-related sequences mapped onto the PAD structure reveals that the conservation mainly includes residues found within the hydrophobic core of the protein, defining a common lipocalin-like fold for this enzyme family. A narrow cleft containing several conserved amino acids was observed as a structural feature and a potential ligand-binding site.


===Crystal Structure of Phenolic Acid Decarboxylase from Bacillus pumilus UI-670===
Structural analysis of Bacillus pumilus phenolic acid decarboxylase, a lipocalin-fold enzyme.,Matte A, Grosse S, Bergeron H, Abokitse K, Lau PC Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt, 11):1407-14. Epub 2010 Oct 27. PMID:21045284<ref>PMID:21045284</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 3nad" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 21045284 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_21045284}}
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</StructureSection>
==About this Structure==
[[3nad]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_pumilus Bacillus pumilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NAD OCA].
 
==Reference==
<ref group="xtra">PMID:021045284</ref><ref group="xtra">PMID:020112419</ref><ref group="xtra">PMID:007684291</ref><ref group="xtra">PMID:011058749</ref><ref group="xtra">PMID:018326577</ref><ref group="xtra">PMID:008534115</ref><references group="xtra"/>
[[Category: Bacillus pumilus]]
[[Category: Bacillus pumilus]]
[[Category: Abokitse, K.]]
[[Category: Large Structures]]
[[Category: Bergeron, H.]]
[[Category: Abokitse K]]
[[Category: Grosse, S.]]
[[Category: Bergeron H]]
[[Category: Lau, P C.K.]]
[[Category: Grosse S]]
[[Category: Matte, A.]]
[[Category: Lau PCK]]
[[Category: Beta barrel]]
[[Category: Matte A]]
[[Category: Biocatalysis]]
[[Category: Decarboxylase]]
[[Category: Lipocalin]]
[[Category: Lyase]]

Latest revision as of 09:12, 6 September 2023

Crystal Structure of Phenolic Acid Decarboxylase from Bacillus pumilus UI-670

3nad, resolution 1.69Å

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