3mqm: Difference between revisions

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[[Image:3mqm.png|left|200px]]


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==Crystal Structure of the Bromodomain of human ASH1L==
The line below this paragraph, containing "STRUCTURE_3mqm", creates the "Structure Box" on the page.
<StructureSection load='3mqm' size='340' side='right'caption='[[3mqm]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3mqm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MQM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MQM FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.54&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mqm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mqm OCA], [https://pdbe.org/3mqm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mqm RCSB], [https://www.ebi.ac.uk/pdbsum/3mqm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mqm ProSAT]</span></td></tr>
{{STRUCTURE_3mqm|  PDB=3mqm  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/ASH1L_HUMAN ASH1L_HUMAN] Histone methyltransferase specifically methylating 'Lys-36' of histone H3 (H3K36me).<ref>PMID:21239497</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mq/3mqm_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mqm ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Bromodomains (BRDs) are protein interaction modules that specifically recognize epsilon-N-lysine acetylation motifs, a key event in the reading process of epigenetic marks. The 61 BRDs in the human genome cluster into eight families based on structure/sequence similarity. Here, we present 29 high-resolution crystal structures, covering all BRD families. Comprehensive crossfamily structural analysis identifies conserved and family-specific structural features that are necessary for specific acetylation-dependent substrate recognition. Screening of more than 30 representative BRDs against systematic histone-peptide arrays identifies new BRD substrates and reveals a strong influence of flanking posttranslational modifications, such as acetylation and phosphorylation, suggesting that BRDs recognize combinations of marks rather than singly acetylated sequences. We further uncovered a structural mechanism for the simultaneous binding and recognition of diverse diacetyl-containing peptides by BRD4. These data provide a foundation for structure-based drug design of specific inhibitors for this emerging target family.


===Crystal Structure of the Bromodomain of human ASH1L===
Histone recognition and large-scale structural analysis of the human bromodomain family.,Filippakopoulos P, Picaud S, Mangos M, Keates T, Lambert JP, Barsyte-Lovejoy D, Felletar I, Volkmer R, Muller S, Pawson T, Gingras AC, Arrowsmith CH, Knapp S Cell. 2012 Mar 30;149(1):214-31. PMID:22464331<ref>PMID:22464331</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_22464331}}, adds the Publication Abstract to the page
<div class="pdbe-citations 3mqm" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 22464331 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_22464331}}
__TOC__
 
</StructureSection>
==About this Structure==
[[3mqm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MQM OCA].
 
==Reference==
<ref group="xtra">PMID:022464331</ref><references group="xtra"/>
[[Category: Histone-lysine N-methyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bountra, C.]]
[[Category: Arrowsmith CH]]
[[Category: Canning, P.]]
[[Category: Bountra C]]
[[Category: Chaikuad, A.]]
[[Category: Canning P]]
[[Category: Delft, F von.]]
[[Category: Chaikuad A]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Felletar, I.]]
[[Category: Felletar I]]
[[Category: Filippakopoulos, P.]]
[[Category: Filippakopoulos P]]
[[Category: Keates, T.]]
[[Category: Keates T]]
[[Category: Knapp, S.]]
[[Category: Knapp S]]
[[Category: Krojer, T.]]
[[Category: Krojer T]]
[[Category: Picaud, S.]]
[[Category: Picaud S]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Vollmar M]]
[[Category: Vollmar, M.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Von Delft F]]
[[Category: Absent small and homeotic disks protein 1 homolog]]
[[Category: Ash1]]
[[Category: Ash1l]]
[[Category: Kiaa1420]]
[[Category: Kmt2h]]
[[Category: Lysine n-methyltransferase 2h]]
[[Category: Sgc]]
[[Category: Structural genomics consortium]]
[[Category: Transferase]]

Latest revision as of 08:59, 6 September 2023

Crystal Structure of the Bromodomain of human ASH1L

3mqm, resolution 2.54Å

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