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'''Unreleased structure'''


The entry 4ap8 is ON HOLD
==Crystal structure of human Molybdopterin synthase catalytic subunit (MOCS2B)==
 
<StructureSection load='4ap8' size='340' side='right'caption='[[4ap8]], [[Resolution|resolution]] 2.78&Aring;' scene=''>
Authors: Vollmar, M., Kiyani, W., Krojer, T., Goubin, S., Allerston, C., Froese, D.S., von Delft, F., Burgess-Brown, N., Bountra, C., Arrowsmith, C.H., Edwards, A., Yue, W.W.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4ap8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AP8 FirstGlance]. <br>
Description: Crystal structure of human Molybdopterin synthase catalytic subunit ( MOCS2B)
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.78&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ap8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ap8 OCA], [https://pdbe.org/4ap8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ap8 RCSB], [https://www.ebi.ac.uk/pdbsum/4ap8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ap8 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/MOC2B_HUMAN MOC2B_HUMAN] Molybdenum cofactor deficiency type B (MOCOD type B) [MIM:[https://omim.org/entry/252150 252150]: Autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death. Note=The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/MOC2B_HUMAN MOC2B_HUMAN] Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.<ref>PMID:12732628</ref> <ref>PMID:15073332</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Allerston C]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Burgess-Brown N]]
[[Category: Edwards A]]
[[Category: Froese DS]]
[[Category: Goubin S]]
[[Category: Kiyani W]]
[[Category: Krojer T]]
[[Category: Vollmar M]]
[[Category: Yue WW]]
[[Category: Von Delft F]]
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