4egl: Difference between revisions
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New page: '''Unreleased structure''' The entry 4egl is ON HOLD Authors: Wang, H, Zeng, F, Liu, H, Teng, M, Li, X Description: Crystal structure of two tandem RNA recognition motifs of Human anti... |
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==Crystal structure of two tandem RNA recognition motifs of Human antigen R== | |||
<StructureSection load='4egl' size='340' side='right'caption='[[4egl]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4egl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EGL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MLY:N-DIMETHYL-LYSINE'>MLY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4egl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4egl OCA], [https://pdbe.org/4egl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4egl RCSB], [https://www.ebi.ac.uk/pdbsum/4egl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4egl ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ELAV1_HUMAN ELAV1_HUMAN] Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro.<ref>PMID:19029303</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Li X]] | |||
[[Category: Liu H]] | |||
[[Category: Teng M]] | |||
[[Category: Wang H]] | |||
[[Category: Zeng F]] | |||
