3v1v: Difference between revisions

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[[Image:3v1v.jpg|left|200px]]


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==Crystal structure of 2-methylisoborneol synthase from Streptomyces coelicolor A3(2) in complex with Mg2+ and geranyl-S-thiolodiphosphate==
The line below this paragraph, containing "STRUCTURE_3v1v", creates the "Structure Box" on the page.
<StructureSection load='3v1v' size='340' side='right'caption='[[3v1v]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3v1v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_coelicolor_A3(2) Streptomyces coelicolor A3(2)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V1V FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GST:GERANYL+S-THIOLODIPHOSPHATE'>GST</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_3v1v|  PDB=3v1v  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v1v OCA], [https://pdbe.org/3v1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v1v RCSB], [https://www.ebi.ac.uk/pdbsum/3v1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v1v ProSAT]</span></td></tr>
 
</table>
===Crystal structure of 2-methylisoborneol synthase from Streptomyces coelicolor A3(2) in complex with Mg2+ and geranyl-S-thiolodiphosphate===
== Function ==
 
[https://www.uniprot.org/uniprot/MIBS_STRCO MIBS_STRCO] Catalyzes the cyclization of 2-methylgeranyl diphosphate (2-MeGPP) to 2-methylisoborneol (2-MIB), which likely involves the intermediacy of 2-methyllinalyl diphosphate. Is also able to catalyze the cyclization of geranyl diphosphate (GPP), albeit with much lower efficiency, leading to the formation of a complex mixture of cyclic monoterpenes, consisting of alpha-pinene (6%), beta-pinene (23%), limonene (32%), gamma-terpinene (29%), and delta-terpinene (10%).
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_22455514}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 22455514 is the PubMed ID number.
[[Category: Christianson DW]]
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[[Category: Koksal M]]
{{ABSTRACT_PUBMED_22455514}}
 
==About this Structure==
[[3v1v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptomyces_coelicolor Streptomyces coelicolor]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V1V OCA].  
 
==Reference==
<ref group="xtra">PMID:022455514</ref><references group="xtra"/>
[[Category: Streptomyces coelicolor]]
[[Category: Christianson, D W.]]
[[Category: Koksal, M.]]
[[Category: 2-methylisoborneol biosynthesis]]
[[Category: Biosynthesis of 2-methylisoborneol]]
[[Category: Class i terpenoid cyclase fold]]
[[Category: Ddxxxxd motif]]
[[Category: Lyase]]
[[Category: Ndxxsxxxe motif]]

Latest revision as of 10:29, 1 March 2024

Crystal structure of 2-methylisoborneol synthase from Streptomyces coelicolor A3(2) in complex with Mg2+ and geranyl-S-thiolodiphosphate

3v1v, resolution 1.80Å

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