3ulb: Difference between revisions

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[[Image:3ulb.jpg|left|200px]]


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==Crystal structure of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1, a TORC2 subunit, in the P212121 crystal form==
The line below this paragraph, containing "STRUCTURE_3ulb", creates the "Structure Box" on the page.
<StructureSection load='3ulb' size='340' side='right'caption='[[3ulb]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ulb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ULB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ULB FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ulb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ulb OCA], [https://pdbe.org/3ulb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ulb RCSB], [https://www.ebi.ac.uk/pdbsum/3ulb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ulb ProSAT]</span></td></tr>
{{STRUCTURE_3ulb|  PDB=3ulb  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/AVO1_YEAST AVO1_YEAST] Component of TORC2, which regulates cell cycle-dependent polarization of the actin-cytoskeleton and cell wall integrity. TORC2 controls polarity of the actin cytoskeleton, which is required for orienting the secretory pathway toward discrete growth sites, via the RHO1/PKC1/MAPK cell integrity pathway.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
In eukaryotes, multiprotein complexes termed TOR complex 1 (TORC1) and TOR complex 2 (TORC2) function as major regulators of cell growth, metabolism and ageing. The C-terminal domain of the Saccharomyces cerevisiae TORC2 component Avo1 is required for plasma-membrane localization of TORC2 and is essential for yeast viability. X-ray crystal structures of the C-terminal domain of Avo1 and of its human orthologue Sin1 have been determined. The structures show that the C-termini of Avo1 and Sin1 both have the pleckstrin homology (PH) domain fold. Comparison with known PH-domain structures suggests a putative binding site for phosphoinositides.


===Crystal structure of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1, a TORC2 subunit, in the P212121 crystal form===
Structures of the pleckstrin homology domain of Saccharomyces cerevisiae Avo1 and its human orthologue Sin1, an essential subunit of TOR complex 2.,Pan D, Matsuura Y Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Apr 1;68(Pt 4):386-92., Epub 2012 Mar 27. PMID:22505404<ref>PMID:22505404</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==About this Structure==
</div>
[[3ulb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ULB OCA].
<div class="pdbe-citations 3ulb" style="background-color:#fffaf0;"></div>
[[Category: Saccharomyces cerevisiae]]
== References ==
[[Category: Matsuura, Y.]]
<references/>
[[Category: Pan, D.]]
__TOC__
[[Category: Membrane localization]]
</StructureSection>
[[Category: Membrane protein]]
[[Category: Large Structures]]
[[Category: Ph domain]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Matsuura Y]]
[[Category: Pan D]]
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