4d9o: Difference between revisions

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[[Image:4d9o.jpg|left|200px]]


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==Structure of ebolavirus protein VP24 from Reston==
The line below this paragraph, containing "STRUCTURE_4d9o", creates the "Structure Box" on the page.
<StructureSection load='4d9o' size='340' side='right'caption='[[4d9o]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[4d9o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Reston_ebolavirus_-_Reston Reston ebolavirus - Reston]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4D9O FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4d9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4d9o OCA], [https://pdbe.org/4d9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4d9o RCSB], [https://www.ebi.ac.uk/pdbsum/4d9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4d9o ProSAT]</span></td></tr>
{{STRUCTURE_4d9o|  PDB=4d9o  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/VP24_EBORE VP24_EBORE] Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways. Blocks the IFN-induced nuclear accumulation of host phosphorylated STAT1, by interacting with the STAT1-binding region of host importin alpha-1/KPNA1 protein, thereby inhibiting the latter. Without the activity of this protein, activated STAT1 would not enter the nucleus and be unable to activate IFN-induced genes. Plays a role in assembly of viral nucleocapsid and virion budding. May act as a minor matrix protein that plays a role in assembly of viral nucleocapsid and virion budding.


===Structure of ebolavirus protein VP24 from Reston===
==See Also==
 
*[[VP24|VP24]]
 
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</StructureSection>
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[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 22383882 is the PubMed ID number.
[[Category: Reston ebolavirus - Reston]]
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[[Category: Zhang APP]]
{{ABSTRACT_PUBMED_22383882}}
 
==About this Structure==
[[4d9o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Reston_ebolavirus Reston ebolavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4D9O OCA].
 
==Reference==
<ref group="xtra">PMID:022383882</ref><references group="xtra"/>
[[Category: Reston ebolavirus]]
[[Category: Zhang, A P.P.]]
[[Category: Ebolavirus]]
[[Category: Ifn response pathway]]
[[Category: Interferon antagonist]]
[[Category: Karyopherin alpha]]
[[Category: Reston]]
[[Category: Stat1]]
[[Category: Sudan]]
[[Category: Viral protein]]
[[Category: Vp24]]
[[Category: Vp35]]
[[Category: Zaire]]
Retrieved from "https://proteopedia.org/4d9o"