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[[Image:3tp0.png|left|200px]]


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==Structural activation of the transcriptional repressor EthR from M. tuberculosis by single amino-acid change mimicking natural and synthetic ligands==
The line below this paragraph, containing "STRUCTURE_3tp0", creates the "Structure Box" on the page.
<StructureSection load='3tp0' size='340' side='right'caption='[[3tp0]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3tp0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TP0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FO5:3-OXO-3-{4-[3-(THIOPHEN-2-YL)-1,2,4-OXADIAZOL-5-YL]PIPERIDIN-1-YL}PROPANENITRILE'>FO5</scene></td></tr>
{{STRUCTURE_3tp0|  PDB=3tp0  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tp0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tp0 OCA], [https://pdbe.org/3tp0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tp0 RCSB], [https://www.ebi.ac.uk/pdbsum/3tp0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tp0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>


===Structural activation of the transcriptional repressor EthR from M. tuberculosis by single amino-acid change mimicking natural and synthetic ligands===
==See Also==
 
*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
 
== References ==
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<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_22156370}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 22156370 is the PubMed ID number.
</StructureSection>
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[[Category: Large Structures]]
{{ABSTRACT_PUBMED_22156370}}
 
==About this Structure==
[[3tp0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TP0 OCA].
 
==Reference==
<ref group="xtra">PMID:022156370</ref><references group="xtra"/>
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Baulard, A.]]
[[Category: Baulard A]]
[[Category: Blondiaux, N.]]
[[Category: Blondiaux N]]
[[Category: Carette, X.]]
[[Category: Carette X]]
[[Category: Deprez, B.]]
[[Category: Deprez B]]
[[Category: Diri , B.]]
[[Category: Diri B]]
[[Category: England, P.]]
[[Category: England P]]
[[Category: Hoos, S.]]
[[Category: Fr nois F]]
[[Category: Lecat-Guillet, N.]]
[[Category: Hoos S]]
[[Category: Lens, Z.]]
[[Category: Lecat-Guillet N]]
[[Category: Lippens, G.]]
[[Category: Lens Z]]
[[Category: Locht, C.]]
[[Category: Lippens G]]
[[Category: Soror, S.]]
[[Category: Locht C]]
[[Category: Villeret, V.]]
[[Category: Soror S]]
[[Category: Willand, N.]]
[[Category: Villeret V]]
[[Category: Willery, E.]]
[[Category: Willand N]]
[[Category: Wintjens, R.]]
[[Category: Willery E]]
[[Category: Wohlkonig, A.]]
[[Category: Wintjens R]]
[[Category: Nois, F Fr.]]
[[Category: Wohlkonig A]]
[[Category: Dna binding protein]]
[[Category: Tetr-family]]
[[Category: Transcription-inhibitor complex]]
[[Category: Transcritptional regulatory repressor]]

Latest revision as of 10:10, 1 March 2024

Structural activation of the transcriptional repressor EthR from M. tuberculosis by single amino-acid change mimicking natural and synthetic ligands

3tp0, resolution 1.90Å

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