2zvr: Difference between revisions

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[[Image:2zvr.png|left|200px]]


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==Crystal structure of a D-tagatose 3-epimerase-related protein from Thermotoga maritima==
The line below this paragraph, containing "STRUCTURE_2zvr", creates the "Structure Box" on the page.
<StructureSection load='2zvr' size='340' side='right'caption='[[2zvr]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2zvr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZVR FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zvr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zvr OCA], [https://pdbe.org/2zvr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zvr RCSB], [https://www.ebi.ac.uk/pdbsum/2zvr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zvr ProSAT]</span></td></tr>
{{STRUCTURE_2zvr|  PDB=2zvr  |  SCENE=  }}
</table>
 
== Function ==
===Crystal structure of a D-tagatose 3-epimerase-related protein from Thermotoga maritima===
[https://www.uniprot.org/uniprot/IOLO_THEMA IOLO_THEMA] Catalyzes the reversible epimerization between 5-keto-L-gluconate (5-dehydro-L-gluconate) and D-tagaturonate, and thus probably functions in a myo-inositol degradation pathway together with IolG, IolM and IolN (PubMed:23441918). Is not active on the enantiomer 5-keto-D-gluconate (PubMed:23441918). Was also shown to be a nonphosphorylated sugar isomerase with broad substrate specificity in vitro (PubMed:28258150). Is able to catalyze the reversible C3-epimerization of L-ribulose to L-xylulose, D-ribulose to D-xylulose, D-psicose to D-fructose, and D-tagatose to D-sorbose, with a substrate preference for ketopentoses rather than ketohexoses (PubMed:28258150). Also catalyzes the aldose-ketose isomerization reaction from either D-erythrose or D-threose to D-erythrulose (PubMed:28258150). Exhibits no activity for C4-epimerization of D-tagatose to D-fructose (PubMed:28258150).<ref>PMID:23441918</ref> <ref>PMID:28258150</ref>
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
<!--
Check<jmol>
The line below this paragraph, {{ABSTRACT_PUBMED_19255464}}, adds the Publication Abstract to the page
  <jmolCheckbox>
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zv/2zvr_consurf.spt"</scriptWhenChecked>
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    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
{{ABSTRACT_PUBMED_19255464}}
    <text>to colour the structure by Evolutionary Conservation</text>
 
  </jmolCheckbox>
==About this Structure==
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2zvr ConSurf].
[[2zvr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZVR OCA].  
<div style="clear:both"></div>
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:019255464</ref><references group="xtra"/>
__TOC__
[[Category: Thermotoga maritima]]
</StructureSection>
[[Category: Ohshima, T.]]
[[Category: Large Structures]]
[[Category: Sakuraba, H.]]
[[Category: D-tagatose 3-epimerase]]
[[Category: Hyperthermophile]]
[[Category: Isomerase]]
[[Category: Ketohexose 3-epimerase]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
[[Category: Ohshima T]]
[[Category: Sakuraba H]]

Latest revision as of 13:58, 13 March 2024

Crystal structure of a D-tagatose 3-epimerase-related protein from Thermotoga maritima

2zvr, resolution 2.20Å

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