4enn: Difference between revisions
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New page: '''Unreleased structure''' The entry 4enn is ON HOLD Authors: Tubbs, JL, Arvai, AS, Tainer, JA Description: Crystal structure of S. pombe Atl1 in complex with damaged DNA containing O6... |
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==Crystal structure of S. pombe Atl1 in complex with damaged DNA containing O6-carboxymethylguanine== | |||
<StructureSection load='4enn' size='340' side='right'caption='[[4enn]], [[Resolution|resolution]] 2.84Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4enn]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ENN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ENN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8448Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C6G:6-(CARBOXYMETHOXY)-9-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-9H-PURIN-2-AMINE'>C6G</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4enn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4enn OCA], [https://pdbe.org/4enn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4enn RCSB], [https://www.ebi.ac.uk/pdbsum/4enn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4enn ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ATL1_SCHPO ATL1_SCHPO] Acts as a DNA damage recognition factor. Required for DNA repair from mutagenic O(6)-alkylguanine adducts. Binds O(6)-alkylguanine lesions providing a signal for other DNA repair pathways. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Schizosaccharomyces pombe 972h-]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Arvai AS]] | |||
[[Category: Tainer JA]] | |||
[[Category: Tubbs JL]] | |||
Latest revision as of 15:05, 14 March 2024
Crystal structure of S. pombe Atl1 in complex with damaged DNA containing O6-carboxymethylguanine
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