4eq1: Difference between revisions
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==Crystal Structure of the ARNT PAS-B homodimer== | |||
<StructureSection load='4eq1' size='340' side='right'caption='[[4eq1]], [[Resolution|resolution]] 1.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4eq1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EQ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EQ1 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PE5:3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL'>PE5</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eq1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eq1 OCA], [https://pdbe.org/4eq1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eq1 RCSB], [https://www.ebi.ac.uk/pdbsum/4eq1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eq1 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ARNT_HUMAN ARNT_HUMAN] Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia. | |||
==See Also== | |||
*[[3D structures of hypoxia-inducible factor|3D structures of hypoxia-inducible factor]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Gardner KH]] | |||
[[Category: Key JM]] | |||
Latest revision as of 15:07, 14 March 2024
Crystal Structure of the ARNT PAS-B homodimer
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