Sandbox Reserved 475: Difference between revisions
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Acetylcholine receptor proteins are present in the peripheral nervous system (PNS) as well as the central nervous system (CNS) in humans and many organisms, including invertebrates. The function of the receptor follows a general mechanism to which it is applied to almost any organism with a nervous system, that relies on the firing action potentials of the neurons.<ref>Guzman, F. Acetylcholine receptors: muscarinic and nicotinic. http://pharmacologycorner.com/acetylcholine-receptors-muscarinic-and-nicotinic/#what</ref> The structure depicted to the right is a redering of the the nicotinic acetylcholine receptor extracted from [http://en.wikipedia.org/wiki/Marbled_electric_ray Torpedo marmorata], more commonly known as the Marbled Electric Ray. Specifically, it is extracted from the electric organ's tissue from within the organism.<ref name="Refined">Unwin N. (March 4, 2005). "Refined structure of the nicotinic acetylcholine receptor at 4A resolution". Journal of Molecular Biology 346 (4): 967–89. doi:10.1016/j.jmb.2004.12.031. PMID 15701510.</ref> | Acetylcholine receptor proteins are present in the peripheral nervous system (PNS) as well as the central nervous system (CNS) in humans and many organisms, including invertebrates. The function of the receptor follows a general mechanism to which it is applied to almost any organism with a nervous system, that relies on the firing action potentials of the neurons.<ref>Guzman, F. Acetylcholine receptors: muscarinic and nicotinic. http://pharmacologycorner.com/acetylcholine-receptors-muscarinic-and-nicotinic/#what</ref> The structure depicted to the right is a redering of the the nicotinic acetylcholine receptor extracted from [http://en.wikipedia.org/wiki/Marbled_electric_ray Torpedo marmorata], more commonly known as the Marbled Electric Ray. Specifically, it is extracted from the electric organ's tissue from within the organism.<ref name="Refined">Unwin N. (March 4, 2005). "Refined structure of the nicotinic acetylcholine receptor at 4A resolution". Journal of Molecular Biology 346 (4): 967–89. doi:10.1016/j.jmb.2004.12.031. PMID 15701510.</ref> | ||
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Nicotinic Acetylcholine Receptor is composed up '''five distinct subunits''' (shown in figure to left): '''α1''', '''α2''', '''β1''', '''δ''', and '''ε''' at approximately a molecular mass of 290 kDa. The subunits are symmetrically arranged around a central pore. Each subunit is a transmembrane domain with the <scene name='Sandbox_Reserved_475/My_scene_4/2'>N-terminus (in blue)</scene>and<scene name='Sandbox_Reserved_475/My_scene_4/2'>C-terminus (in red)</scene> located on the extracellular side of the plasma membrane. Each subunit are composed of long protein chains that extend across the cell membrane. The subunits have a composition of around '''~20%''' <scene name='Sandbox_Reserved_475/My_scene_2/1'>beta sheets</scene> and '''~40%''' <scene name='Sandbox_Reserved_475/My_scene/1'>alpha helices</scene> from about ~370 residues in total.<ref name="Refined"/> | Nicotinic Acetylcholine Receptor is composed up '''five distinct subunits''' (shown in figure to left): '''α1''', '''α2''', '''β1''', '''δ''', and '''ε''' at approximately a molecular mass of 290 kDa. The subunits are symmetrically arranged around a central pore. Each subunit is a transmembrane domain with the <scene name='Sandbox_Reserved_475/My_scene_4/2'>N-terminus (in blue)</scene> and <scene name='Sandbox_Reserved_475/My_scene_4/2'>C-terminus (in red)</scene> located on the extracellular side of the plasma membrane. Each subunit are composed of long protein chains that extend across the cell membrane. The subunits have a composition of around '''~20%''' <scene name='Sandbox_Reserved_475/My_scene_2/1'>beta sheets</scene> and '''~40%''' <scene name='Sandbox_Reserved_475/My_scene/1'>alpha helices</scene> from about ~370 residues in total.<ref name="Refined"/> | ||
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