4ew4: Difference between revisions

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'''Unreleased structure'''


The entry 4ew4 is ON HOLD
==mouse MBD4 glycosylase domain in complex with DNA containing a ribose sugar==
<StructureSection load='4ew4' size='340' side='right'caption='[[4ew4]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ew4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EW4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EW4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.791&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ew4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ew4 OCA], [https://pdbe.org/4ew4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ew4 RCSB], [https://www.ebi.ac.uk/pdbsum/4ew4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ew4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MBD4_MOUSE MBD4_MOUSE] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.


Authors: Hashimoto, H., Zhang, X., Cheng, X.
==See Also==
 
*[[Methyl CpG binding protein 3D structures|Methyl CpG binding protein 3D structures]]
Description: mouse MBD4 glycosylase domain in complex with DNA containing a ribose sugar
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Synthetic construct]]
[[Category: Cheng X]]
[[Category: Hashimoto H]]
[[Category: Zhang X]]
Retrieved from "https://proteopedia.org/4ew4"