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[[Image:1pdg.jpg|left|200px]]<br /><applet load="1pdg" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1pdg, resolution 3.0&Aring;" />
'''CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB'''<br />


==Overview==
==CRYSTAL STRUCTURE OF HUMAN PLATELET-DERIVED GROWTH FACTOR BB==
The crystal structure of the homodimeric BB isoform of human recombinant, platelet-derived growth factor (PDGF-BB) has been determined by X-ray, analysis to 3.0 A resolution. The polypeptide chain is folded into two, highly twisted antiparallel pairs of beta-strands and contains an unusual, knotted arrangement of three intramolecular disulfide bonds. Dimerization, leads to the clustering of three surface loops at each end of the, elongated dimer, which most probably form the receptor recognition sites.
<StructureSection load='1pdg' size='340' side='right'caption='[[1pdg]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
 
== Structural highlights ==
==Disease==
<table><tr><td colspan='2'>[[1pdg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PDG FirstGlance]. <br>
Known diseases associated with this structure: Dermatofibrosarcoma protuberans OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190040 190040]], Giant-cell fibroblastoma OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190040 190040]], Meningioma, SIS-related OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=190040 190040]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pdg OCA], [https://pdbe.org/1pdg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pdg RCSB], [https://www.ebi.ac.uk/pdbsum/1pdg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pdg ProSAT]</span></td></tr>
==About this Structure==
</table>
1PDG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PDG OCA].  
== Disease ==
 
[https://www.uniprot.org/uniprot/PDGFB_HUMAN PDGFB_HUMAN] Note=A chromosomal aberration involving PDGFB is found in dermatofibrosarcoma protuberans. Translocation t(17;22)(q22;q13) with PDGFB.<ref>PMID:12660034</ref>
==Reference==
== Function ==
Crystal structure of human platelet-derived growth factor BB., Oefner C, D'Arcy A, Winkler FK, Eggimann B, Hosang M, EMBO J. 1992 Nov;11(11):3921-6. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=1396586 1396586]
[https://www.uniprot.org/uniprot/PDGFB_HUMAN PDGFB_HUMAN] Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pd/1pdg_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1pdg ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Darcy, A.D.]]
[[Category: Darcy AD]]
[[Category: Eggimann, B.]]
[[Category: Eggimann B]]
[[Category: Hosnag, M.]]
[[Category: Hosnag M]]
[[Category: Oefner, C.]]
[[Category: Oefner C]]
[[Category: Winkler, F.K.]]
[[Category: Winkler FK]]
[[Category: growth factor]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:39:53 2008''
Retrieved from "https://proteopedia.org/1pdg"