4asx: Difference between revisions
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New page: '''Unreleased structure''' The entry 4asx is ON HOLD Authors: Williams, E., Chaikuad, A., Canning, P., Mahajan, P., Cooper, C.D.O., Beltrami, A., Krojer, T., Huber, K., Bracher, F., von... |
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==Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dihydro-Bauerine C== | |||
<StructureSection load='4asx' size='340' side='right'caption='[[4asx]], [[Resolution|resolution]] 2.05Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4asx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ASX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ASX FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6OJ:7,8-BIS(CHLORANYL)-9-METHYL-3,4-DIHYDRO-2H-PYRIDO[3,4-B]INDOL-1-ONE'>6OJ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4asx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4asx OCA], [https://pdbe.org/4asx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4asx RCSB], [https://www.ebi.ac.uk/pdbsum/4asx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4asx ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/AVR2A_HUMAN AVR2A_HUMAN] On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Arrowsmith CH]] | |||
[[Category: Beltrami A]] | |||
[[Category: Bountra C]] | |||
[[Category: Bracher F]] | |||
[[Category: Bullock A]] | |||
[[Category: Canning P]] | |||
[[Category: Chaikuad A]] | |||
[[Category: Cooper CDO]] | |||
[[Category: Edwards AM]] | |||
[[Category: Kochan G]] | |||
[[Category: Krojer T]] | |||
[[Category: Mahajan P]] | |||
[[Category: Pohl B]] | |||
[[Category: Williams E]] | |||
[[Category: Von Delft F]] | |||
Latest revision as of 11:34, 20 December 2023
Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dihydro-Bauerine C
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