4eyl: Difference between revisions
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The | ==Crystal structure of NDM-1 bound to hydrolyzed meropenem== | ||
<StructureSection load='4eyl' size='340' side='right'caption='[[4eyl]], [[Resolution|resolution]] 1.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4eyl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. The July 2015 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''New Delhi Metallo-b-Lactamase'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2015_7 10.2210/rcsb_pdb/mom_2015_7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EYL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EYL FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0RV:(2S)-2-[(1S,2R)-1-CARBOXY-2-HYDROXYPROPYL]-4-{[(3S,5S)-5-(DIMETHYLCARBAMOYL)PYRROLIDIN-3-YL]SULFANYL}-3-METHYL-2H-PYRROLE-5-CARBOXYLIC+ACID'>0RV</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4eyl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4eyl OCA], [https://pdbe.org/4eyl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4eyl RCSB], [https://www.ebi.ac.uk/pdbsum/4eyl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4eyl ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. | |||
==See Also== | |||
*[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Klebsiella pneumoniae]] | |||
[[Category: Large Structures]] | |||
[[Category: New Delhi Metallo-b-Lactamase]] | |||
[[Category: RCSB PDB Molecule of the Month]] | |||
[[Category: King DT]] | |||
[[Category: Strynadka NCJ]] | |||
Latest revision as of 11:06, 1 March 2024
Crystal structure of NDM-1 bound to hydrolyzed meropenem
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