4ez1: Difference between revisions

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'''Unreleased structure'''


The entry 4ez1 is ON HOLD
==Crystal structure of acetylcholine binding protein (AChBP) from Aplysia Californica in complex with alpha-conotoxin BuIA==
<StructureSection load='4ez1' size='340' side='right'caption='[[4ez1]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[4ez1]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Aplysia_californica Aplysia californica] and [https://en.wikipedia.org/wiki/Conus_bullatus Conus bullatus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EZ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EZ1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ez1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ez1 OCA], [https://pdbe.org/4ez1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ez1 RCSB], [https://www.ebi.ac.uk/pdbsum/4ez1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ez1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CA1A_CONBU CA1A_CONBU] Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This peptide potently blocks numerous mammalian nAChR subtypes (alpha-6 or -3/beta-2 or -3 > alpha-6 or-3/beta-4 > alpha-3/beta-2 > alpha-3/beta-4 > alpha-4/beta-4 = alpha-2/beta-4 > alpha-7 > alpha-2/beta-2 >> alpha-4/beta-2). Recovery from toxin block is markedly slower for beta-4 versus beta-2 subunit-containing nAChRs. Thus, it represents a novel probe for distinguishing between beta-2 and beta-4-containing nAChRs.


Authors: Talley, T.T., Reger, A.S., Kim, C., Sankaran, B, Ho, K., Taylor, P, McIntosh, J.M.
==See Also==
 
*[[Acetylcholine binding protein 3D structures|Acetylcholine binding protein 3D structures]]
Description: Crystal structure of acetylcholine binding protein (AChBP) from Aplysia Californica in complex with alpha-conotoxin BuIA
__TOC__
</StructureSection>
[[Category: Aplysia californica]]
[[Category: Conus bullatus]]
[[Category: Large Structures]]
[[Category: Ho K]]
[[Category: Kim C]]
[[Category: McIntosh JM]]
[[Category: Reger AS]]
[[Category: Sankaran B]]
[[Category: Talley TT]]
[[Category: Taylor P]]
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