4edz: Difference between revisions

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[[Image:4edz.jpg|left|200px]]


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==Crystal structure of hH-PGDS with water displacing inhibitor==
The line below this paragraph, containing "STRUCTURE_4edz", creates the "Structure Box" on the page.
<StructureSection load='4edz' size='340' side='right'caption='[[4edz]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[4edz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EDZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EDZ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0O5:4-(3-METHYLISOQUINOLIN-1-YL)-N-[2-(MORPHOLIN-4-YL)ETHYL]BENZAMIDE'>0O5</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_4edz|  PDB=4edz  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4edz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4edz OCA], [https://pdbe.org/4edz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4edz RCSB], [https://www.ebi.ac.uk/pdbsum/4edz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4edz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HPGDS_HUMAN HPGDS_HUMAN] Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide.<ref>PMID:10824118</ref> <ref>PMID:11672424</ref> <ref>PMID:9425264</ref> <ref>PMID:9353279</ref> <ref>PMID:12627223</ref> <ref>PMID:15113825</ref> <ref>PMID:16547010</ref> <ref>PMID:19939518</ref>


===Crystal structure of hH-PGDS with water displacing inhibitor===
==See Also==
 
*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
 
== References ==
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{{ABSTRACT_PUBMED_22546671}}
 
==About this Structure==
[[4edz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EDZ OCA].
 
==Reference==
<ref group="xtra">PMID:022546671</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Day, J E.]]
[[Category: Large Structures]]
[[Category: Thorarensen, A.]]
[[Category: Day JE]]
[[Category: Trujillo, J I.]]
[[Category: Thorarensen A]]
[[Category: Inhibitor]]
[[Category: Trujillo JI]]
[[Category: Isomerase-isomerase inhibitor complex]]
[[Category: Solvent replacement]]
Retrieved from "https://proteopedia.org/4edz"