4er7: Difference between revisions

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[[Image:4er7.jpg|left|200px]]


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==Crystal Structure of human DOT1L in complex with inhibitor SGC0947==
The line below this paragraph, containing "STRUCTURE_4er7", creates the "Structure Box" on the page.
<StructureSection load='4er7' size='340' side='right'caption='[[4er7]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[4er7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ER7 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AW3:5-BROMO-7-{5-[(3-{[(4-TERT-BUTYLPHENYL)CARBAMOYL]AMINO}PROPYL)AMINO]-5-DEOXY-BETA-D-RIBOFURANOSYL}-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE'>AW3</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
{{STRUCTURE_4er7|  PDB=4er7  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4er7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4er7 OCA], [https://pdbe.org/4er7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4er7 RCSB], [https://www.ebi.ac.uk/pdbsum/4er7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4er7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DOT1L_HUMAN DOT1L_HUMAN] Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.


===Crystal Structure of human DOT1L in complex with inhibitor SGC0947===
==See Also==
 
*[[Histone methyltransferase 3D structures|Histone methyltransferase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
[[4er7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ER7 OCA].
[[Category: Histone-lysine N-methyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Bountra, C.]]
[[Category: Arrowsmith CH]]
[[Category: Bradner, J E.]]
[[Category: Bountra C]]
[[Category: Brown, P J.]]
[[Category: Bradner JE]]
[[Category: Edwards, A M.]]
[[Category: Brown PJ]]
[[Category: Li, Y.]]
[[Category: Edwards AM]]
[[Category: Nguyen, K T.]]
[[Category: Li Y]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Nguyen KT]]
[[Category: Schapira, M.]]
[[Category: Schapira M]]
[[Category: Scopton, A.]]
[[Category: Scopton A]]
[[Category: Tempel, W.]]
[[Category: Tempel W]]
[[Category: Vedadi, M.]]
[[Category: Vedadi M]]
[[Category: Wernimont, A K.]]
[[Category: Wernimont AK]]
[[Category: Yu, W.]]
[[Category: Yu W]]
[[Category: Epigenetic]]
[[Category: Histone]]
[[Category: Methyltransferase]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/4er7"