4f8c: Difference between revisions

(7 intermediate revisions by the same user not shown)

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 4f8c is ~~ON HOLD~~

==Structure of the Cif:Nedd8 complex - Yersinia pseudotuberculosis Cycle Inhibiting Factor in complex with human Nedd8==

== Structural highlights ==

<table><tr><td colspan='2'>[[4f8c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Yersinia_pseudotuberculosis_YPIII Yersinia pseudotuberculosis YPIII]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F8C OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=4F8C FirstGlance].

</td></tr><tr id='method'><td class="sblockLbl">[[Empirical_models|Method:]]</td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95Å</td></tr>

<tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=4f8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f8c OCA], [https://pdbe.org/4f8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f8c RCSB], [https://www.ebi.ac.uk/pdbsum/4f8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f8c ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/CIF_YERPY CIF_YERPY] Protein-glutamine deamidase effector that inhibits the host cell cycle and other key cellular processes such as the actin network and programmed-cell death (PubMed:19308257, PubMed:22691497). Acts by mediating the side chain deamidation of 'Gln-40' of host NEDD8, converting it to glutamate, thereby abolishing the activity of cullin-RING-based E3 ubiquitin-protein ligase complexes (CRL complexes) (PubMed:22691497). Inactivation of CRL complexes prevents ubiquitination and subsequent degradation of the cyclin-dependent kinase inhibitors CDKN1A/p21 and CDKN1B/p27, leading to G1 and G2 cell cycle arrests in host cells (PubMed:19308257). Also able to catalyze deamidation of 'Gln-40' of host ubiquitin in vitro; however, NEDD8 constitutes the preferred substrate in vivo (By similarity).[UniProtKB:Q63KH5]<ref>PMID:19308257</ref> <ref>PMID:22691497</ref>

~~Authors~~: ~~Crow, A., Banfield, M~~

==See Also==

*[[NEDD8|NEDD8]]

~~Description~~: ~~Structure of the Cif:Nedd8 complex -~~Yersinia pseudotuberculosis ~~Cycle Inhibiting Factor in complex with human Nedd8~~

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Yersinia pseudotuberculosis YPIII]]

[[Category: Banfield M]]

[[Category: Crow A]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4f8c is ON HOLD
+==Structure of the Cif:Nedd8 complex - Yersinia pseudotuberculosis Cycle Inhibiting Factor in complex with human Nedd8==
+<StructureSection load='4f8c' size='340' side='right'caption='[[4f8c]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4f8c]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Yersinia_pseudotuberculosis_YPIII Yersinia pseudotuberculosis YPIII]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4F8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4F8C FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4f8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4f8c OCA], [https://pdbe.org/4f8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4f8c RCSB], [https://www.ebi.ac.uk/pdbsum/4f8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4f8c ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/CIF_YERPY CIF_YERPY] Protein-glutamine deamidase effector that inhibits the host cell cycle and other key cellular processes such as the actin network and programmed-cell death (PubMed:19308257, PubMed:22691497). Acts by mediating the side chain deamidation of 'Gln-40' of host NEDD8, converting it to glutamate, thereby abolishing the activity of cullin-RING-based E3 ubiquitin-protein ligase complexes (CRL complexes) (PubMed:22691497). Inactivation of CRL complexes prevents ubiquitination and subsequent degradation of the cyclin-dependent kinase inhibitors CDKN1A/p21 and CDKN1B/p27, leading to G1 and G2 cell cycle arrests in host cells (PubMed:19308257). Also able to catalyze deamidation of 'Gln-40' of host ubiquitin in vitro; however, NEDD8 constitutes the preferred substrate in vivo (By similarity).[UniProtKB:Q63KH5]<ref>PMID:19308257</ref> <ref>PMID:22691497</ref>
-Authors: Crow, A., Banfield, M
+==See Also==
+*[[NEDD8|NEDD8]]
-Description: Structure of the Cif:Nedd8 complex -Yersinia pseudotuberculosis Cycle Inhibiting Factor in complex with human Nedd8
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Yersinia pseudotuberculosis YPIII]]
+[[Category: Banfield M]]
+[[Category: Crow A]]