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[[Image:1ugv.jpg|left|200px]]<br /><applet load="1ugv" size="350" color="white" frame="true" align="right" spinBox="true"
caption="1ugv" />
'''Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)'''<br />


==Disease==
==Solution structure of the SH3 domain of human olygophrein-1 like protein (KIAA0621)==
Known diseases associated with this structure: Leukemia, juvenile myelomonocytic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=605370 605370]]
<StructureSection load='1ugv' size='340' side='right'caption='[[1ugv]]' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[1ugv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UGV FirstGlance]. <br>
1UGV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UGV OCA].  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ugv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ugv OCA], [https://pdbe.org/1ugv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ugv RCSB], [https://www.ebi.ac.uk/pdbsum/1ugv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ugv ProSAT], [https://www.topsan.org/Proteins/RSGI/1ugv TOPSAN]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN] Defects in ARHGAP26 are a cause of juvenile myelomonocytic leukemia (JMML) [MIM:[https://omim.org/entry/607785 607785]. JMML is a pediatric myelodysplastic syndrome that constitutes approximately 30% of childhood cases of myelodysplastic syndrome (MDS) and 2% of leukemia. Chromosomal translocation t(5;11)(q31;q23) with MLL has been found in a JMML patient.
== Function ==
[https://www.uniprot.org/uniprot/RHG26_HUMAN RHG26_HUMAN] GTPase-activating protein for RHOA and CDC42.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ug/1ugv_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ugv ConSurf].
<div style="clear:both"></div>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Aoki, M.]]
[[Category: Aoki M]]
[[Category: Hayashi, F.]]
[[Category: Hayashi F]]
[[Category: Hirota, H.]]
[[Category: Hirota H]]
[[Category: Inoue, K.]]
[[Category: Inoue K]]
[[Category: Inoue, M.]]
[[Category: Inoue M]]
[[Category: Kigawa, T.]]
[[Category: Kigawa T]]
[[Category: Kikuno, R.]]
[[Category: Kikuno R]]
[[Category: Matsuda, T.]]
[[Category: Matsuda T]]
[[Category: Matsuo, Y.]]
[[Category: Matsuo Y]]
[[Category: Nagase, T.]]
[[Category: Nagase T]]
[[Category: Nakayama, M.]]
[[Category: Nakayama M]]
[[Category: Ohara, O.]]
[[Category: Ohara O]]
[[Category: Osanai, T.]]
[[Category: Osanai T]]
[[Category: RSGI, RIKEN.Structural.Genomics/Proteomics.Initiative.]]
[[Category: Seki E]]
[[Category: Seki, E.]]
[[Category: Shirouzu M]]
[[Category: Shirouzu, M.]]
[[Category: Tanaka A]]
[[Category: Tanaka, A.]]
[[Category: Terada T]]
[[Category: Terada, T.]]
[[Category: Yabuki T]]
[[Category: Yabuki, T.]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S.]]
[[Category: Yoshida M]]
[[Category: Yoshida, M.]]
[[Category: beta barrel]]
[[Category: graf protein]]
[[Category: riken structural genomics/proteomics initiative]]
[[Category: rsgi]]
[[Category: structural genomics]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 17:02:17 2008''
Retrieved from "https://proteopedia.org/1ugv"