4egk: Difference between revisions

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[[Image:4egk.jpg|left|200px]]


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==Human Hsp90-alpha ATPase domain bound to Radicicol==
The line below this paragraph, containing "STRUCTURE_4egk", creates the "Structure Box" on the page.
<StructureSection load='4egk' size='340' side='right'caption='[[4egk]], [[Resolution|resolution]] 1.69&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[4egk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4EGK FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.69&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RDC:RADICICOL'>RDC</scene></td></tr>
{{STRUCTURE_4egk|  PDB=4egk  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4egk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4egk OCA], [https://pdbe.org/4egk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4egk RCSB], [https://www.ebi.ac.uk/pdbsum/4egk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4egk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>  


===Human Hsp90-alpha ATPase domain bound to Radicicol===
==See Also==
 
*[[Heat Shock Protein structures|Heat Shock Protein structures]]
 
== References ==
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<references/>
The line below this paragraph, {{ABSTRACT_PUBMED_22573733}}, adds the Publication Abstract to the page
__TOC__
(as it appears on PubMed at http://www.pubmed.gov), where 22573733 is the PubMed ID number.
</StructureSection>
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{{ABSTRACT_PUBMED_22573733}}
 
==About this Structure==
[[4egk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EGK OCA].
 
==Reference==
<ref group="xtra">PMID:022573733</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Chen, W J.]]
[[Category: Large Structures]]
[[Category: Wood, S P.]]
[[Category: Chen WJ]]
[[Category: Bergerat fold]]
[[Category: Wood SP]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
Retrieved from "https://proteopedia.org/4egk"