3t03: Difference between revisions

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[[Image:3t03.jpg|left|200px]]


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==Crystal structure of PPAR gamma ligand binding domain in complex with a novel partial agonist GQ-16==
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<StructureSection load='3t03' size='340' side='right'caption='[[3t03]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3t03]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T03 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3T03 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3T0:(5Z)-5-(5-BROMO-2-METHOXYBENZYLIDENE)-3-(4-METHYLBENZYL)-1,3-THIAZOLIDINE-2,4-DIONE'>3T0</scene></td></tr>
{{STRUCTURE_3t03|  PDB=3t03  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3t03 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3t03 OCA], [https://pdbe.org/3t03 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3t03 RCSB], [https://www.ebi.ac.uk/pdbsum/3t03 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3t03 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Note=Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer.  Defects in PPARG may be associated with susceptibility to obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:9753710</ref>  Defects in PPARG are the cause of familial partial lipodystrophy type 3 (FPLD3) [MIM:[https://omim.org/entry/604367 604367]. Familial partial lipodystrophies (FPLD) are a heterogeneous group of genetic disorders characterized by marked loss of subcutaneous (sc) fat from the extremities. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.<ref>PMID:12453919</ref> <ref>PMID:11788685</ref>  Genetic variations in PPARG can be associated with susceptibility to glioma type 1 (GLM1) [MIM:[https://omim.org/entry/137800 137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
== Function ==
[https://www.uniprot.org/uniprot/PPARG_HUMAN PPARG_HUMAN] Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.<ref>PMID:9065481</ref> <ref>PMID:16150867</ref> <ref>PMID:20829347</ref>  


===Crystal structure of PPAR gamma ligand binding domain in complex with a novel partial agonist GQ-16===
==See Also==
 
*[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]]
 
== References ==
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{{ABSTRACT_PUBMED_22584573}}
 
==About this Structure==
[[3t03]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3T03 OCA].
 
==Reference==
<ref group="xtra">PMID:022584573</ref><references group="xtra"/>
[[Category: Histone acetyltransferase]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Baxter, J D.]]
[[Category: Large Structures]]
[[Category: Brennan, R G.]]
[[Category: Baxter JD]]
[[Category: Phillips, K J.]]
[[Category: Brennan RG]]
[[Category: Rajagopalan, S.]]
[[Category: Phillips KJ]]
[[Category: Webb, P.]]
[[Category: Rajagopalan S]]
[[Category: Ligand binding protein]]
[[Category: Webb P]]
[[Category: Nucleus receptor]]
[[Category: Protein-drug complex]]
[[Category: Thiazolidinedione]]
[[Category: Transcription factor]]
[[Category: Transcription-transcription regulator complex]]
Retrieved from "https://proteopedia.org/3t03"