4ed5: Difference between revisions
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==Crystal structure of the two N-terminal RRM domains of HuR complexed with RNA== | |||
<StructureSection load='4ed5' size='340' side='right'caption='[[4ed5]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4ed5]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ED5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ED5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=M2M:1-METHOXY-2-(2-METHOXYETHOXY)ETHANE'>M2M</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ed5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ed5 OCA], [https://pdbe.org/4ed5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ed5 RCSB], [https://www.ebi.ac.uk/pdbsum/4ed5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ed5 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ELAV1_HUMAN ELAV1_HUMAN] Involved in 3'-UTR ARE-mediated MYC stabilization. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, HUR binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro.<ref>PMID:19029303</ref> | |||
== References == | |||
== | <references/> | ||
[[4ed5]] is a 4 chain structure with sequence from [ | __TOC__ | ||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Li | [[Category: Large Structures]] | ||
[[Category: Liu | [[Category: Li X]] | ||
[[Category: Niu | [[Category: Liu Q]] | ||
[[Category: Teng | [[Category: Niu L]] | ||
[[Category: Wang | [[Category: Teng M]] | ||
[[Category: Zeng | [[Category: Wang H]] | ||
[[Category: Zeng F]] | |||
Latest revision as of 08:49, 20 March 2024
Crystal structure of the two N-terminal RRM domains of HuR complexed with RNA
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