Agrin: Difference between revisions

(16 intermediate revisions by 3 users not shown)

Line 1:

~~[[Image:3i70.jpg|left|200px|thumb|Crystal Structure of chicken Agrin,~~ [[3i70]]]]

~~{{STRUCTURE_3i70| PDB~~=~~3i70 | SIZE~~=~~400| SCENE~~=~~Agrin/Cv/1 |right|CAPTION~~=~~chicken Agrin, [[3i70]] }}~~

__TOC__

== Function ==

[[Agrin]] (Agr) is involved in the embryogenesis of the neuromuscular junction. It is involved in the aggregation of acetylcholine receptors. ~~Its N-terminal domain NtA binds laminin. The C-terminal of Agr has 3 laminin binding domains (LMB)~~: ~~G1-G3. The images at the left and at the right correspond to one representative Agrin, ''i.e.'' the crystal structure of chicken Agrin ([[3i70]]).~~

[[Agrin]] (Agr) is involved in the embryogenesis of the neuromuscular junction. It is involved in the aggregation of acetylcholine receptors. <ref>PMID:7852425</ref>

~~{{TOC limit|limit~~=~~2}}~~

== Relevance ==

Agr is an inducer of mammalian heart regeneration<ref>PMID:28581497</ref>.

== Disease ==

Agr is overexpressed in brains of Alzheimer Disease patients. Agr is associated with myasthenic syndrome.

== Structural highlights ==

Agr N-terminal domain binds laminin. The C-terminal of Agr has 3 laminin-like globular domains (LMB) G1-G3 and 4 epidermal growth factor-like domains. Agr binds heparan sulfate post-translationally. Other Agr domains are: Kazal type serine protease inhibitor.

== 3D Structures of Agrin ==

[[Agrin 3D structures]]

~~[[3i70]], [[1pxu]] – cNtA – chicken~~

</StructureSection>

~~[[1pz7]], [[1pz8]], [[1pz9]] – cAgr ~~

~~[[1q56]] – cAgr LMB G3+Ca – NMR ~~

~~[[1jb3]], [[1jc7]] – cAgr LMB ~~

~~[[3pve]] – Agr LMB G2 - mouse ~~

~~[[3v65]] – Agr LMB G3 + Low-density lipoprotein receptor-related protein 4 - rat~~

== References ==

[[Category:Topic Page]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:3i70.jpg|left|200px|thumb|Crystal Structure of chicken Agrin, [[3i70]]]]
+<StructureSection load='' size='350' side='right' caption='Chicken agrin (PDB code [[3i70]]).' scene='41/417482/Cv/2'>
-{{STRUCTURE_3i70|  PDB=3i70  | SIZE=400| SCENE=Agrin/Cv/1 |right|CAPTION=chicken Agrin, [[3i70]] }}
+__TOC__
+== Function ==
-[[Agrin]] (Agr) is involved in the embryogenesis of the neuromuscular junction.  It is involved in the aggregation of acetylcholine receptors.  Its N-terminal domain NtA binds laminin. The C-terminal of Agr has 3 laminin binding domains (LMB): G1-G3. The images at the left and at the right correspond to one representative Agrin, ''i.e.'' the crystal structure of chicken Agrin ([[3i70]]).
+[[Agrin]] (Agr) is involved in the embryogenesis of the neuromuscular junction.  It is involved in the aggregation of acetylcholine receptors. <ref>PMID:7852425</ref>
-{{TOC limit|limit=2}}
+== Relevance ==
+Agr is an inducer of mammalian heart regeneration<ref>PMID:28581497</ref>.
+== Disease ==
+Agr is overexpressed in brains of Alzheimer Disease patients.  Agr is associated with myasthenic syndrome.
+== Structural highlights ==
+Agr N-terminal domain binds laminin. The C-terminal of Agr has 3 laminin-like globular domains (LMB) G1-G3 and 4 epidermal growth factor-like domains. Agr binds heparan sulfate post-translationally.  Other Agr domains are: Kazal type serine protease inhibitor.
 == 3D Structures of Agrin ==
+[[Agrin 3D structures]]
-[[3i70]], [[1pxu]] – cNtA – chicken<br />
+</StructureSection>
-[[1pz7]], [[1pz8]], [[1pz9]] – cAgr<br />
-[[1q56]] – cAgr LMB G3+Ca – NMR<br />
-[[1jb3]], [[1jc7]] – cAgr LMB<br />
-[[3pve]] – Agr LMB G2 - mouse<br />
-[[3v65]] – Agr LMB G3 + Low-density lipoprotein receptor-related protein 4 - rat
+== References ==
+<references/>
 [[Category:Topic Page]]