4pfk: Difference between revisions

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==PHOSPHOFRUCTOKINASE. STRUCTURE AND CONTROL==
The line below this paragraph, containing "STRUCTURE_4pfk", creates the "Structure Box" on the page.
<StructureSection load='4pfk' size='340' side='right'caption='[[4pfk]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[4pfk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. The February 2004 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''The Glycolytic Enzymes''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2004_2 10.2210/rcsb_pdb/mom_2004_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PFK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4PFK FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=F6P:FRUCTOSE-6-PHOSPHATE'>F6P</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_4pfk|  PDB=4pfk  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4pfk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pfk OCA], [https://pdbe.org/4pfk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4pfk RCSB], [https://www.ebi.ac.uk/pdbsum/4pfk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4pfk ProSAT]</span></td></tr>
 
</table>
===PHOSPHOFRUCTOKINASE. STRUCTURE AND CONTROL===
== Function ==
 
[https://www.uniprot.org/uniprot/PFKA_GEOSE PFKA_GEOSE] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_00339]<ref>PMID:8136379</ref>
 
== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pf/4pfk_consurf.spt"</scriptWhenChecked>
{{ABSTRACT_PUBMED_6115424}}
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    <text>to colour the structure by Evolutionary Conservation</text>
==About this Structure==
  </jmolCheckbox>
[[4pfk]] is a 1 chain structure of [[Phosphofructokinase (PFK)]] with sequence from [http://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus]. The February 2004 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''The Glycolytic Enzymes''  by David S. Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2004_2 10.2210/rcsb_pdb/mom_2004_2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PFK OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=4pfk ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[Phosphofructokinase (PFK)|Phosphofructokinase (PFK)]]
*[[Phosphofructokinase (PFK)|Phosphofructokinase (PFK)]]
 
*[[Phosphofructokinase 3D structures|Phosphofructokinase 3D structures]]
==Reference==
== References ==
<ref group="xtra">PMID:006115424</ref><references group="xtra"/>
<references/>
[[Category: 6-phosphofructokinase]]
__TOC__
</StructureSection>
[[Category: Geobacillus stearothermophilus]]
[[Category: Geobacillus stearothermophilus]]
[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: The Glycolytic Enzymes]]
[[Category: The Glycolytic Enzymes]]
[[Category: Evans, P R.]]
[[Category: Evans PR]]
[[Category: Hudson, P J.]]
[[Category: Hudson PJ]]

Latest revision as of 12:42, 1 March 2024

PHOSPHOFRUCTOKINASE. STRUCTURE AND CONTROL

4pfk, resolution 2.40Å

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