2haq: Difference between revisions

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[[Image:2haq.png|left|200px]]


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==Crystal Structure of Cyclophilin A from Leishmania Donovani==
The line below this paragraph, containing "STRUCTURE_2haq", creates the "Structure Box" on the page.
<StructureSection load='2haq' size='340' side='right'caption='[[2haq]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2haq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Leishmania_donovani Leishmania donovani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HAQ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2haq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2haq OCA], [https://pdbe.org/2haq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2haq RCSB], [https://www.ebi.ac.uk/pdbsum/2haq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2haq ProSAT]</span></td></tr>
{{STRUCTURE_2haq|  PDB=2haq  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9U9R3_LEIDO Q9U9R3_LEIDO] PPIases accelerate the folding of proteins.[RuleBase:RU000493]  PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.[RuleBase:RU004223]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ha/2haq_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2haq ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of cyclophilin from Leishmania donovani (LdCyp) has been determined and refined at 1.97 A resolution to a crystallographic R factor of 0.178 (R(free) = 0.197). The structure was solved by molecular replacement using cyclophilin from Trypanosoma cruzi as the search model. LdCyp exhibits complete structural conservation of the cyclosporin-binding site with respect to the homologous human protein, as anticipated from LdCyp-cyclosporin binding studies. Comparisons with other cyclophilins show deviations primarily in the loop regions. The solvent structure encompassing the molecule has also been analyzed in some detail.


===Crystal Structure of Cyclophilin A from Leishmania Donovani===
Structure of cyclophilin from Leishmania donovani at 1.97 A resolution.,Venugopal V, Sen B, Datta AK, Banerjee R Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Feb 1;63(Pt, 2):60-4. Epub 2007 Jan 17. PMID:17277440<ref>PMID:17277440</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2haq" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 17277440 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17277440}}
 
==About this Structure==
[[2haq]] is a 1 chain structure of [[Cyclophilin]] with sequence from [http://en.wikipedia.org/wiki/Leishmania_donovani Leishmania donovani]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HAQ OCA].


==See Also==
==See Also==
*[[Cyclophilin|Cyclophilin]]
*[[Cyclophilin 3D structures|Cyclophilin 3D structures]]
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:017277440</ref><references group="xtra"/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Leishmania donovani]]
[[Category: Leishmania donovani]]
[[Category: Peptidylprolyl isomerase]]
[[Category: Banerjee R]]
[[Category: Banerjee., R.]]
[[Category: Datta AK]]
[[Category: Datta, A K.]]
[[Category: Sen B]]
[[Category: Sen, B.]]
[[Category: Venugopal V]]
[[Category: Venugopal, V.]]
[[Category: Cis-tran]]
[[Category: Cyclophilin]]
[[Category: Donovani]]
[[Category: Isomerase]]
[[Category: Kala-azar.]]
[[Category: Leishmania]]
[[Category: Proline]]
[[Category: Protozoa]]
[[Category: Rotamase]]

Latest revision as of 09:54, 30 August 2023

Crystal Structure of Cyclophilin A from Leishmania Donovani

2haq, resolution 1.97Å

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