2b56: Difference between revisions

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==Structural Basis for UTP Specificity of RNA Editing TUTases From Trypanosoma Brucei==
The line below this paragraph, containing "STRUCTURE_2b56", creates the "Structure Box" on the page.
<StructureSection load='2b56' size='340' side='right'caption='[[2b56]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2b56]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B56 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B56 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=U5P:URIDINE-5-MONOPHOSPHATE'>U5P</scene>, <scene name='pdbligand=UTP:URIDINE+5-TRIPHOSPHATE'>UTP</scene></td></tr>
{{STRUCTURE_2b56|  PDB=2b56  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b56 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b56 OCA], [https://pdbe.org/2b56 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b56 RCSB], [https://www.ebi.ac.uk/pdbsum/2b56 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b56 ProSAT]</span></td></tr>
 
</table>
===Structural Basis for UTP Specificity of RNA Editing TUTases From Trypanosoma Brucei===
== Function ==
 
[https://www.uniprot.org/uniprot/TUT2_TRYBB TUT2_TRYBB] Terminal uridylyltransferase which, as part of the mitochondrial RNA editing core complex (RECC), is involved in the post-transcriptional editing of mitochondrial RNA, a process involving the addition and deletion of uridine (U) nucleotides in the pre-mRNA (PubMed:12820966, PubMed:19465686, PubMed:20362585). Specifically, catalyzes the addition of one U to single-stranded RNA with a preference for a 3'-terminal A or G and adds the number of Us specified by a guide RNA (gRNA) to precleaved double-stranded RNA editing substrates (PubMed:12820966, PubMed:19465686, PubMed:20362585, PubMed:16281058). Essential for the survival of the bloodstream form (PubMed:16281058).<ref>PMID:12820966</ref> <ref>PMID:16281058</ref> <ref>PMID:19465686</ref> <ref>PMID:20362585</ref>
 
== Evolutionary Conservation ==
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==About this Structure==
  </jmolCheckbox>
[[2b56]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B56 OCA].  
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b56 ConSurf].
 
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==Reference==
== References ==
<ref group="xtra">PMID:016281058</ref><ref group="xtra">PMID:017785418</ref><references group="xtra"/>
<references/>
[[Category: Trypanosoma brucei]]
__TOC__
[[Category: Deng, J.]]
</StructureSection>
[[Category: Ernst, N L.]]
[[Category: Large Structures]]
[[Category: Hol, W G.]]
[[Category: Stuart, K D.]]
[[Category: Turley, S.]]
[[Category: Rna editing]]
[[Category: Tbret2]]
[[Category: Transferase]]
[[Category: Transferase-rna binding protein complex]]
[[Category: Trypanosoma brucei]]
[[Category: Trypanosoma brucei]]
[[Category: Tutase]]
[[Category: Deng J]]
[[Category: Ernst NL]]
[[Category: Hol WG]]
[[Category: Stuart KD]]
[[Category: Turley S]]
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