3mlt: Difference between revisions

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[[Image:3mlt.png|left|200px]]


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==Crystal structure of anti-HIV-1 V3 Fab 2557 in complex with a UG1033 V3 peptide==
The line below this paragraph, containing "STRUCTURE_3mlt", creates the "Structure Box" on the page.
<StructureSection load='3mlt' size='340' side='right'caption='[[3mlt]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3mlt]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MLT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MLT FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.49&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mlt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mlt OCA], [https://pdbe.org/3mlt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mlt RCSB], [https://www.ebi.ac.uk/pdbsum/3mlt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mlt ProSAT]</span></td></tr>
{{STRUCTURE_3mlt|  PDB=3mlt  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q9WNX3_9HIV1 Q9WNX3_9HIV1]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ml/3mlt_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mlt ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Binding of the third variable region (V3) of the HIV-1 envelope glycoprotein gp120 to the cell-surface coreceptors CCR5 or CXCR4 during viral entry suggests that there are conserved structural elements in this sequence-variable region. These conserved elements could serve as epitopes to be targeted by a vaccine against HIV-1. Here we perform a systematic structural analysis of representative human anti-V3 monoclonal antibodies in complex with V3 peptides, revealing that the crown of V3 has four conserved structural elements: an arch, a band, a hydrophobic core and the peptide backbone. These are either unaffected by or are subject to minimal sequence variation. As these regions are targeted by cross-clade neutralizing human antibodies, they provide a blueprint for the design of vaccine immunogens that could elicit broadly cross-reactive protective antibodies.


===Crystal structure of anti-HIV-1 V3 Fab 2557 in complex with a UG1033 V3 peptide===
Conserved structural elements in the V3 crown of HIV-1 gp120.,Jiang X, Burke V, Totrov M, Williams C, Cardozo T, Gorny MK, Zolla-Pazner S, Kong XP Nat Struct Mol Biol. 2010 Aug;17(8):955-61. Epub 2010 Jul 11. PMID:20622876<ref>PMID:20622876</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_20622876}}, adds the Publication Abstract to the page
<div class="pdbe-citations 3mlt" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 20622876 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_20622876}}
 
==About this Structure==
[[3mlt]] is a 10 chain structure of [[Antibody]] and [[Monoclonal Antibody]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MLT OCA].


==See Also==
==See Also==
*[[Antibody|Antibody]]
*[[Monoclonal Antibodies 3D structures|Monoclonal Antibodies 3D structures]]
*[[Monoclonal Antibody|Monoclonal Antibody]]
== References ==
 
<references/>
==Reference==
__TOC__
<ref group="xtra">PMID:020622876</ref><references group="xtra"/>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
[[Category: Kong, X P.]]
[[Category: Large Structures]]
[[Category: Antibody-antigen interaction]]
[[Category: Kong X-P]]
[[Category: Fab]]
[[Category: Gp120]]
[[Category: Hiv-1]]
[[Category: Human monoclonal antibody]]
[[Category: Immune system]]
[[Category: Third variable loop]]

Latest revision as of 10:11, 6 November 2024

Crystal structure of anti-HIV-1 V3 Fab 2557 in complex with a UG1033 V3 peptide

3mlt, resolution 2.49Å

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