1pg1: Difference between revisions
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< | ==PROTEGRIN 1 (PG1) FROM PORCINE LEUKOCYTES, NMR, 20 STRUCTURES== | ||
<StructureSection load='1pg1' size='340' side='right'caption='[[1pg1]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[1pg1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PG1 FirstGlance]. <br> | |||
or | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
-- | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pg1 OCA], [https://pdbe.org/1pg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pg1 RCSB], [https://www.ebi.ac.uk/pdbsum/1pg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pg1 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PG1_PIG PG1_PIG] Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
BACKGROUND: The protegrins are a family of arginine- and cysteine-rich cationic peptides found in porcine leukocytes that exhibit a broad range of antimicrobial and antiviral activities. They are composed of 16-18 amino-acid residues including four cysteines, which form two disulfide linkages. To begin to understand the mechanism of action of these peptides, we set out to determine the structure of protegrin-1 (PG-1). RESULTS: We used two-dimensional homonuclear nuclear magnetic resonance spectroscopy to study the conformation of both natural and synthetic PG-1 under several conditions. A refined three-dimensional structure of synthetic PG-1 is presented. CONCLUSIONS: Both synthetic and natural protegrin-1 form a well-defined structure in solution composed primarily of a two-stranded antiparallel beta sheet, with strands connected by a beta turn. The structure of PG-1 suggests ways in which the peptide may interact with itself or other molecules to form the membrane pores and the large membrane-associated assemblages observed in protegrin-treated, gram-negative bacteria. | |||
Solution structure of protegrin-1, a broad-spectrum antimicrobial peptide from porcine leukocytes.,Fahrner RL, Dieckmann T, Harwig SS, Lehrer RI, Eisenberg D, Feigon J Chem Biol. 1996 Jul;3(7):543-50. PMID:8807886<ref>PMID:8807886</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 1pg1" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Protegrin|Protegrin]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
== | [[Category: Large Structures]] | ||
[[ | |||
== | |||
< | |||
[[Category: Sus scrofa]] | [[Category: Sus scrofa]] | ||
[[Category: Dieckmann | [[Category: Dieckmann T]] | ||
[[Category: Eisenberg | [[Category: Eisenberg D]] | ||
[[Category: Fahrner | [[Category: Fahrner RL]] | ||
[[Category: Feigon | [[Category: Feigon J]] | ||
[[Category: Harwig | [[Category: Harwig SSL]] | ||
[[Category: Lehrer | [[Category: Lehrer RI]] | ||
Latest revision as of 00:22, 21 November 2024
PROTEGRIN 1 (PG1) FROM PORCINE LEUKOCYTES, NMR, 20 STRUCTURES
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