1vxr: Difference between revisions

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==O-ETHYLMETHYLPHOSPHONYLATED ACETYLCHOLINESTERASE OBTAINED BY REACTION WITH O-ETHYL-S-[2-[BIS(1-METHYLETHYL)AMINO]ETHYL] METHYLPHOSPHONOTHIOATE (VX)==
The line below this paragraph, containing "STRUCTURE_1vxr", creates the "Structure Box" on the page.
<StructureSection load='1vxr' size='340' side='right'caption='[[1vxr]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1vxr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetronarce_californica Tetronarce californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VXR FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=VX:O-ETHYLMETHYLPHOSPHONIC+ACID+ESTER+GROUP'>VX</scene></td></tr>
{{STRUCTURE_1vxr|  PDB=1vxr  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vxr OCA], [https://pdbe.org/1vxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vxr RCSB], [https://www.ebi.ac.uk/pdbsum/1vxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vxr ProSAT]</span></td></tr>
 
</table>
===O-ETHYLMETHYLPHOSPHONYLATED ACETYLCHOLINESTERASE OBTAINED BY REACTION WITH O-ETHYL-S-[2-[BIS(1-METHYLETHYL)AMINO]ETHYL] METHYLPHOSPHONOTHIOATE (VX)===
== Function ==
 
[https://www.uniprot.org/uniprot/ACES_TETCF ACES_TETCF] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions.
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
[[1vxr]] is a 1 chain structure of [[Acetylcholinesterase]] with sequence from [http://en.wikipedia.org/wiki/Torpedo_californica Torpedo californica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VXR OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vx/1vxr_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vxr ConSurf].
<div style="clear:both"></div>


==See Also==
==See Also==
*[[AChE inhibitors and substrates|AChE inhibitors and substrates]]
*[[Acetylcholinesterase 3D structures|Acetylcholinesterase 3D structures]]
*[[AChE inhibitors and substrates (Part III)|AChE inhibitors and substrates (Part III)]]
__TOC__
*[[Acetylcholinesterase|Acetylcholinesterase]]
</StructureSection>
*[[Alzheimer's Disease|Alzheimer's Disease]]
[[Category: Large Structures]]
[[Category: Acetylcholinesterase]]
[[Category: Tetronarce californica]]
[[Category: Torpedo californica]]
[[Category: Koellner G]]
[[Category: Koellner, G.]]
[[Category: Millard CB]]
[[Category: Millard, C B.]]
[[Category: Silman I]]
[[Category: Silman, I.]]
[[Category: Sussman JL]]
[[Category: Sussman, J L.]]
[[Category: Chemical-warfare]]
[[Category: Cholinesterase]]
[[Category: Hydrolase]]
[[Category: Organophosphate]]
[[Category: Serine hydrolase]]

Latest revision as of 07:29, 9 October 2024

O-ETHYLMETHYLPHOSPHONYLATED ACETYLCHOLINESTERASE OBTAINED BY REACTION WITH O-ETHYL-S-[2-[BIS(1-METHYLETHYL)AMINO]ETHYL] METHYLPHOSPHONOTHIOATE (VX)

1vxr, resolution 2.20Å

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